A simple LC–MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: Assay development, validation and application in depression patients - Zhai, Xuejia; Chen, Fen; Zhu, Chaoran; Lu, Yongning (Journal of pharmaceutical and biomedical analysis, 2015)
Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism; 11β-HSD; Adult; Case-Control Studies; Cholestenone 5 alpha-Reductase - metabolism; Chromatography, Liquid - methods; Cortisol; Cortisone - chemistry; Cortisone - metabolism; Cortisone - urine; Depression; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - urine; Glucocorticoids - chemistry; Glucocorticoids - metabolism; Glucocorticoids - urine; Humans; Hydrocortisone - chemistry; Hydrocortisone - metabolism; Hydrocortisone - urine; LC–MS/MS; Male; Middle Aged; Reductase; Tandem Mass Spectrometry - methods; Tetrahydrocortisol - analogs & derivatives; Tetrahydrocortisol - chemistry; Tetrahydrocortisol - metabolism; Tetrahydrocortisol - urine; Tetrahydrocortisone - chemistry; Tetrahydrocortisone - metabolism; Tetrahydrocortisone - urine; Young Adult; 11β-HSD; Depression; Cortisol; LC–MS/MS; Reductase