Comparison of Fibroblast and Osteoblast Response to Cultivation on Titanium Implants with Different Grain Sizes

The in vitro response of human fibroblast cell line HFL1 and human osteoblast cell line hFOB 1.19 on nanostructured titanium with different grain sizes has been compared in the present study. Used samples of titanium produced by equal channel angular (ECA) pressing have grain sizes of 160 nm, 280 nm...

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Published inJournal of nanomaterials Vol. 2015; no. 2015; pp. 1 - 9
Main Authors Hrusak, Daniel, Bolek, Lukas, Moztarzadeh, Amin, Kripnerova, Michaela, Kulda, Vlastimil, Dobra, Jana, Babuska, Vaclav, Lahoda, Jiri
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2015
Hindawi Limited
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Abstract The in vitro response of human fibroblast cell line HFL1 and human osteoblast cell line hFOB 1.19 on nanostructured titanium with different grain sizes has been compared in the present study. Used samples of titanium produced by equal channel angular (ECA) pressing have grain sizes of 160 nm, 280 nm, and 2400 nm with cross- and longitudinal sections. Similar cellular behaviour was observed on all studied biomaterials. There were significant differences related to the initial phase of attachment, but not in proliferation. Furthermore, the results indicate that osteoblasts grow best on material with grain size of 160 nm with a longitudinal section in comparison with other examined materials. Therefore, this material could be recommended for further evaluation with respect to osseointegration in vivo.
AbstractList The in vitro response of human fibroblast cell line HFL1 and human osteoblast cell line hFOB 1.19 on nanostructured titanium with different grain sizes has been compared in the present study. Used samples of titanium produced by equal channel angular (ECA) pressing have grain sizes of 160 nm, 280 nm, and 2400 nm with cross- and longitudinal sections. Similar cellular behaviour was observed on all studied biomaterials. There were significant differences related to the initial phase of attachment, but not in proliferation. Furthermore, the results indicate that osteoblasts grow best on material with grain size of 160 nm with a longitudinal section in comparison with other examined materials. Therefore, this material could be recommended for further evaluation with respect to osseointegration in vivo .
Author Moztarzadeh, Amin
Kripnerova, Michaela
Dobra, Jana
Babuska, Vaclav
Hrusak, Daniel
Lahoda, Jiri
Bolek, Lukas
Kulda, Vlastimil
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  fullname: Lahoda, Jiri
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Copyright Copyright © 2015 Vaclav Babuska et al.
Copyright © 2015 Vaclav Babuska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet The in vitro response of human fibroblast cell line HFL1 and human osteoblast cell line hFOB 1.19 on nanostructured titanium with different grain sizes has...
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SubjectTerms Biocompatibility
Biomedical materials
Biotechnology
Cytoskeleton
Fibroblasts
Gene expression
Grain size
Human
Investigations
Mechanical properties
Medicine
Methods
Morphology
Nanomaterials
Proteins
Surgical implants
Titanium
Titanium alloys
Topography
Transplants & implants
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Title Comparison of Fibroblast and Osteoblast Response to Cultivation on Titanium Implants with Different Grain Sizes
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