The role of KLF4 in phagocyte activation during infectious diseases

• Published in: Frontiers in immunology Vol. 16; p. 1584873
• Main Authors: Herta, Toni, Bhattacharyya, Aritra, Hippenstiel, Stefan, Zahlten, Janine
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.04.2025
• Subjects: Animals; Cell Differentiation; Communicable Diseases - immunology; Communicable Diseases - metabolism; dendritic cells; Dendritic Cells - immunology; Humans; Immunity, Innate; Immunology; innate immunity; KLF4; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors - immunology; Kruppel-Like Transcription Factors - metabolism; macrophages; neutrophils; phagocytes; Phagocytes - immunology; Phagocytes - metabolism; transcription factor; macrophages; dendritic cells; phagocytes; innate immunity; KLF4; neutrophils; immune regulation

Phagocytes, including granulocytes (especially neutrophils), monocytes, macrophages, and dendritic cells, are essential components of the innate immune system, bridging innate and adaptive immunity. Their activation and function are tightly regulated by transcription factors that coordinate immune r...