Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19 - G. Moreira, Thais; Gauthier, Christian D.; Murphy, Liam; Lanser, Toby B.; Paul, Anu; Matos, Kimble T. F.; Mangani, Davide; Izzy, Saef; Rezende, Rafael M.; Healy, Brian C.; Baecher-Allan, Clare M.; Chitnis, Tanuja; et al. (Proceedings of the National Academy of Sciences - PNAS, 2023)
Keywords: Administration, Intranasal; Animals; Antibodies, Monoclonal - therapeutic use; Biological Sciences; C-reactive protein; CCL4 protein; CD3 antigen; Coronaviruses; COVID-19; Effector cells; Gene expression; Gene sequencing; GTP-Binding Proteins; Humans; Inflammation; Inflammatory response; Interleukin 6; Intranasal administration; Lymphocytes; Lymphocytes B; Lymphocytes T; Membrane Proteins; Mice; Monoclonal antibodies; Monocytes; Proteomics; Respiratory diseases; rho-Associated Kinases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; T-Lymphocytes; Transcriptomics; Transforming Growth Factor beta1 - genetics; Transforming growth factor-b1; Viral diseases; COVID-19; anti-CD3; SARS-CoV-2; Foralumab; T cells