Gut-liver axis: Pathophysiological concepts and clinical implications

• Published in: Cell metabolism Vol. 34; no. 11; pp. 1700 - 1718
• Main Authors: Tilg, Herbert, Adolph, Timon E., Trauner, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2022
• Subjects: Gastrointestinal Microbiome - physiology; gut microbiome; gut-liver axis; Humans; Inflammation - metabolism; leaky gut; Liver - metabolism; Liver Cirrhosis - metabolism; liver disease; Non-alcoholic Fatty Liver Disease - metabolism; gut microbiome; liver disease; gut-liver axis; leaky gut

Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites, and bile acids regulate metabolism and immune responses in the gut and liver, which reciprocally shape microbial co...