Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The ex...
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Published in | Oncotarget Vol. 8; no. 40; pp. 67269 - 67286 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Impact Journals LLC
15.09.2017
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Subjects | |
Online Access | Get full text |
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