Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

• Published in: Pharmacological research Vol. 114; pp. 251 - 264
• Main Authors: Qiu, Yuan-ye, Tang, Li-qin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2016
• Subjects: Animals; Diabetic Nephropathies - immunology; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Diabetic nephropathy; Humans; Immunity, Innate; Inflammasomes - analysis; Inflammasomes - immunology; Inflammatory response; Kidney - immunology; Kidney - pathology; Kidney - physiopathology; NLR Family, Pyrin Domain-Containing 3 Protein - analysis; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; NLRP3 inflammasome; Pharmacological target; Regulation; Signal Transduction; Signalling pathway; ESRD; NADPH; Tyr (PubChem CID: 6057); JNK; PTK; Arachidonic acid (PubChem CID: 444899); Inflammatory response; DN; ICAM-1; NLRP3 inflammasome; TNF; LRR; AP-1; NF-κB; ASC; Caspase-1 (PubChem CID: 100953062); Thr (PubChem CID: 6288); GFR; Streptozocin (PubChem CID: 29327); Quercetin (PubChem CID: 5280343); Signalling pathway; NLRP3; TGF-β; Diabetic nephropathy; Allopurinol (PubChem CID: 2094); D-Glucose (PubChem CID: 5793); IL; RAGEs; TGF-β (PubChem CID: 56842206); IL-8 (PubChem CID: 44357137); PKC; IR; MAPK; Uric acid (PubChem CID: 1175); ECM; VCAM-1; AIM2; NOS; Angiotensin II (PubChem CID: 172198); Pharmacological target; ROS; TXNIP; Regulation; NLRs; TLRs; ERK; HG

[Display omitted] Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent inflammation in circulatory and renal tissues is an important pathophysiological basis for DN. The essence of the microinflammatory state is the innate immune response, which is central to the...