Bakuchiol: A newly discovered warrior against organ damage
[Display omitted] Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacologica...
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| Published in | Pharmacological research Vol. 141; pp. 208 - 213 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.03.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, antiaging and estrogen-like effects. In addition, recent studies have indicated that BAK exerts protective effects in the heart, liver, skin and other organs. BAK treatment protects the heart against ischemia-reperfusion injury through modulating cardioprotective pathways. BAK also inhibits liver fibrosis via promoting myofibroblast apoptosis and relieves the hepatotoxicity of multiple toxicants by suppressing oxidative stress and inflammatory changes. BAK inhibits the proliferation of various cancer cells, including stomach, breast and skin cancer cells, thereby exerting anticancer effects. Further, BAK effectively slows skin aging by preserving skin collagen. BAK treatment can protect against bone loss and delay osteoporosis by exerting estrogen-like effects. In addition, BAK remarkably reduces blood glucose and triglycerides and might be a potential pharmacological agent that can be used to protect against pancreatic beta-cell damage and diabetes progression. In this review, the pharmacological mechanisms and protective effects of BAK in human diseases are discussed, with a focus on the protective effects of BAK in the heart, liver and other important organs. |
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| AbstractList | [Display omitted]
Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, antiaging and estrogen-like effects. In addition, recent studies have indicated that BAK exerts protective effects in the heart, liver, skin and other organs. BAK treatment protects the heart against ischemia-reperfusion injury through modulating cardioprotective pathways. BAK also inhibits liver fibrosis via promoting myofibroblast apoptosis and relieves the hepatotoxicity of multiple toxicants by suppressing oxidative stress and inflammatory changes. BAK inhibits the proliferation of various cancer cells, including stomach, breast and skin cancer cells, thereby exerting anticancer effects. Further, BAK effectively slows skin aging by preserving skin collagen. BAK treatment can protect against bone loss and delay osteoporosis by exerting estrogen-like effects. In addition, BAK remarkably reduces blood glucose and triglycerides and might be a potential pharmacological agent that can be used to protect against pancreatic beta-cell damage and diabetes progression. In this review, the pharmacological mechanisms and protective effects of BAK in human diseases are discussed, with a focus on the protective effects of BAK in the heart, liver and other important organs. Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, antiaging and estrogen-like effects. In addition, recent studies have indicated that BAK exerts protective effects in the heart, liver, skin and other organs. BAK treatment protects the heart against ischemia-reperfusion injury through modulating cardioprotective pathways. BAK also inhibits liver fibrosis via promoting myofibroblast apoptosis and relieves the hepatotoxicity of multiple toxicants by suppressing oxidative stress and inflammatory changes. BAK inhibits the proliferation of various cancer cells, including stomach, breast and skin cancer cells, thereby exerting anticancer effects. Further, BAK effectively slows skin aging by preserving skin collagen. BAK treatment can protect against bone loss and delay osteoporosis by exerting estrogen-like effects. In addition, BAK remarkably reduces blood glucose and triglycerides and might be a potential pharmacological agent that can be used to protect against pancreatic beta-cell damage and diabetes progression. In this review, the pharmacological mechanisms and protective effects of BAK in human diseases are discussed, with a focus on the protective effects of BAK in the heart, liver and other important organs.Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, antiaging and estrogen-like effects. In addition, recent studies have indicated that BAK exerts protective effects in the heart, liver, skin and other organs. BAK treatment protects the heart against ischemia-reperfusion injury through modulating cardioprotective pathways. BAK also inhibits liver fibrosis via promoting myofibroblast apoptosis and relieves the hepatotoxicity of multiple toxicants by suppressing oxidative stress and inflammatory changes. BAK inhibits the proliferation of various cancer cells, including stomach, breast and skin cancer cells, thereby exerting anticancer effects. Further, BAK effectively slows skin aging by preserving skin collagen. BAK treatment can protect against bone loss and delay osteoporosis by exerting estrogen-like effects. In addition, BAK remarkably reduces blood glucose and triglycerides and might be a potential pharmacological agent that can be used to protect against pancreatic beta-cell damage and diabetes progression. In this review, the pharmacological mechanisms and protective effects of BAK in human diseases are discussed, with a focus on the protective effects of BAK in the heart, liver and other important organs. Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia L., which belongs to the Leguminosae plant family. Previous research has shown that BAK exerts a variety of pharmacological effects, including antioxidant, antibacterial, anti-inflammatory, antiaging and estrogen-like effects. In addition, recent studies have indicated that BAK exerts protective effects in the heart, liver, skin and other organs. BAK treatment protects the heart against ischemia-reperfusion injury through modulating cardioprotective pathways. BAK also inhibits liver fibrosis via promoting myofibroblast apoptosis and relieves the hepatotoxicity of multiple toxicants by suppressing oxidative stress and inflammatory changes. BAK inhibits the proliferation of various cancer cells, including stomach, breast and skin cancer cells, thereby exerting anticancer effects. Further, BAK effectively slows skin aging by preserving skin collagen. BAK treatment can protect against bone loss and delay osteoporosis by exerting estrogen-like effects. In addition, BAK remarkably reduces blood glucose and triglycerides and might be a potential pharmacological agent that can be used to protect against pancreatic beta-cell damage and diabetes progression. In this review, the pharmacological mechanisms and protective effects of BAK in human diseases are discussed, with a focus on the protective effects of BAK in the heart, liver and other important organs. |
| Author | Xin, Zhenlong Sun, Meng Jiang, Shuai Ji, Ting Li, Tian Wu, Xue Xu, Baoping Hu, Wei Han, Yuehu Deng, Chao Yang, Yang |
| Author_xml | – sequence: 1 givenname: Zhenlong surname: Xin fullname: Xin, Zhenlong organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 2 givenname: Xue surname: Wu fullname: Wu, Xue organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 3 givenname: Ting surname: Ji fullname: Ji, Ting organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 4 givenname: Baoping surname: Xu fullname: Xu, Baoping organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 5 givenname: Yuehu surname: Han fullname: Han, Yuehu organization: Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi’an 710032, China – sequence: 6 givenname: Meng surname: Sun fullname: Sun, Meng organization: Department of Cardiology, The First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan 030001, China – sequence: 7 givenname: Shuai surname: Jiang fullname: Jiang, Shuai organization: Department of Aerospace Medicine, The Fourth Military Medical University, 169 Changle West Road, Xi’an 710032, China – sequence: 8 givenname: Tian surname: Li fullname: Li, Tian organization: Graduate School, The Fourth Military Medical University, 169 Changle West Road, Xi’an 710032, China – sequence: 9 givenname: Wei surname: Hu fullname: Hu, Wei organization: Graduate School, The Fourth Military Medical University, 169 Changle West Road, Xi’an 710032, China – sequence: 10 givenname: Chao surname: Deng fullname: Deng, Chao organization: Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi’an, 710061, China – sequence: 11 givenname: Yang surname: Yang fullname: Yang, Yang email: yang200214yy@163.com organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China |
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| Cites_doi | 10.1016/j.ejphar.2010.06.025 10.1016/j.arr.2018.03.004 10.1016/j.bbrc.2013.07.042 10.1002/ptr.972 10.1016/j.ejphar.2014.06.051 10.1155/2014/897296 10.1055/s-2005-864150 10.1155/2015/196914 10.1089/ars.2013.5371 10.1161/CIRCULATIONAHA.113.002480 10.1271/bbb.100221 10.1155/2013/678028 10.1038/cr.2013.169 10.1021/tx034082r 10.1111/j.2042-7158.1996.tb06016.x 10.1016/j.neubiorev.2015.06.008 10.1016/j.phymed.2017.12.030 10.3389/fphar.2016.00128 10.1016/j.neurobiolaging.2013.06.008 10.1002/ijc.31338 10.1016/j.semcancer.2018.02.004 10.1016/0040-4020(73)80071-7 10.3892/mmr.2017.7696 10.1021/np970488q 10.1210/en.2009-0997 10.18632/aging.100396 10.1007/s12031-017-1006-x 10.1016/j.phymed.2009.05.015 10.1089/jmf.2009.1207 10.1016/j.bcp.2010.06.027 10.1146/annurev-neuro-060909-152832 10.1128/AAC.45.11.3009-3013.2001 10.1016/j.ejphar.2007.01.024 10.1016/j.cell.2013.05.039 10.1074/jbc.M110.179242 10.1016/j.bbrc.2018.10.044 10.18632/oncotarget.7524 10.1055/s-0031-1298482 10.1177/1758834017742576 10.3748/wjg.v21.i41.11567 10.1016/j.mce.2015.09.025 10.1111/ics.12117 10.1016/j.fitote.2013.06.016 10.1016/j.neubiorev.2016.10.023 10.1016/S0378-8741(01)00350-6 10.1016/j.phymed.2011.02.002 10.1016/j.nut.2011.04.001 10.1016/0006-2952(95)00088-H 10.3390/molecules200712500 10.1007/s10495-016-1225-6 10.1055/s-2000-8605 10.1016/j.bbadis.2017.11.023 10.1016/j.taap.2013.03.017 10.1111/jpi.12471 10.1007/s10753-016-0481-5 10.1038/s41598-017-08547-0 10.1016/S0040-4039(00)70078-5 10.3390/molecules21081076 10.1016/j.cmet.2012.04.003 10.1248/bpb.22.1137 10.1017/S0007114508066750 10.1016/j.bbadis.2016.11.023 10.4161/auto.29746 |
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| Keywords | D-GalN IRI FOXO Oxidative stress Bakuchiol PKB ERT Inflammation Antibacterial BAK SIRT1 THC ADP-Fe3 GFP MMP Ischemia-reperfusion injury NADH PCE S PI3K CCl4 ROS tBH |
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| References | Ma, Yang, Di, Feng, Liu, Jiang (bib0175) 2017; 7 Parzych, Klionsky (bib0325) 2014; 20 Cui, Taniguchi, Kuroda, Hatano (bib0120) 2015; 20 Feng, Yang, Zhou, Wang, Xiong, Fan (bib0050) 2016; 21 Yu, Zou, Wang, Xu, Li, Zhang (bib0240) 2014; 37 Lee, Yun, Kim, Park, Lee, Oh (bib0030) 2012; 78 Sun, Woo, Cassady, Snapka (bib0115) 1998; 61 Chen, Jin, Gao, Lou, Jin, Yu (bib0035) 2010; 643 Kim, Kim, Lee, Yang, Heo, Bode (bib0195) 2016; 7 Li, Chen, Liu, Lee, Man, Cheng (bib0125) 2016; 7 Lopez-Otin, Blasco, Partridge, Serrano, Kroemer (bib0200) 2013; 153 Lv, Liu (bib0185) 2017; 16 Lim, Ha, Kim, Ahn, Park, Kim (bib0250) 2009; 101 Fiorentini, Zambonin, Dalla Sega, Hrelia (bib0275) 2015; 2015 Lin, Yao, Li (bib0180) 2016; 21 Mehta, Dev (bib0020) 1973; 29 Seo, Lee, Lee, Chun, Lee, Jun (bib0265) 2014; 2014 Adhikari, Joshi, Patro, Ghanty, Chintalwar, Sharma (bib0075) 2003; 16 Haraguchi, Inoue, Tamura, Mizutani (bib0070) 2002; 16 Li, Zhu, Tao, Xin, Liu, Li (bib0160) 2013; 438 Chaudhuri, Bojanowski (bib0245) 2014; 36 Lim, Ha, Ahn, Kim (bib0005) 2011; 18 Lv, Jiang, Yang, Hu, Wang, Li (bib0205) 2018; 44 Lurie, Webb, Cytter-Kuint, Shteingart, Lederkremer (bib0170) 2015; 21 Yang, Jiang, Cheng, Li, Hu, Ma (bib0295) 2017; 9 Song, Jang, Kang (bib0340) 2018; 40 Seo, Oh, Kim, Lee, Chae, Jun (bib0080) 2013; 2013 Katsura, Tsukiyama, Suzuki, Kobayashi (bib0110) 2001; 45 Yang, Duan, Li, Yan, Yi, Liang (bib0150) 2013; 34 Morikiri, Matsuta, Inoue (bib0230) 2018; 505 Reiter, Kim, Quon (bib0300) 2010; 151 Xiang, Nakamura, Lim, Yamasaki, Kurokawa-Nose, Maruyama (bib0290) 2011; 3 Ohno, Watabe, Nakamura, Kawagoshi, Uotsu, Chiba (bib0025) 2010; 74 Chopra, Dhingra, Dhar (bib0010) 2013; 90 Ohsumi (bib0315) 2014; 24 Weng, Gao, Wang, Zhao, Yin, Cai (bib0190) 2015; 417 Newton, McConnell, Hibbert, Graham, Watson (bib0225) 2015; 150 Wang, Zhang, Teng, Zhang, Li (bib0320) 2014; 740 Ma, Xin, Hu, Jiang, Yang, Yan (bib0285) 2018; 50 Zhang, Chang, Zhang, Ye, Han, Li (bib0065) 2017; 40 Mehta, Dev (bib0015) 1966; 7 Ferrandiz, Gil, Sanz, Ubeda, Erazo, Gonzalez (bib0105) 1996; 48 Yang, Duan, Li, Jin, Yan, Yu (bib0145) 2013; 128 Goh (bib0220) 2011; 2 Jiang, Li, Yang, Hu, Yang (bib0280) 2018 Choi, Lee, Choi, Lee, Jo, Ha (bib0100) 2010; 13 Golan, Tirosh, Schwarzfuchs, Harman-Boehm, Thiery, Fiedler (bib0255) 2012; 28 Haraguchi, Inoue, Tamura, Mizutani (bib0095) 2000; 66 Holthoff, Woodling, Doerge, Burns, Hinson, Mayeux (bib0155) 2010; 80 Ballesteros, Kraft, Santana, Tziraki (bib0210) 2015; 55 Sengupta, Molkentin, Paik, DePinho, Yutzey (bib0305) 2011; 286 Zhou, Ma (bib0135) 2018; 64 Park, Zhao, Kim, Sohn (bib0055) 2005; 71 Limtrakul, Yodkeeree, Punfa, Srisomboon (bib0235) 2016; 11 Xin, Ma, Jiang, Wang, Fan, Di (bib0310) 2017; 1863 Price, Gomes, Ling, Duarte, Martin-Montalvo, North (bib0165) 2012; 15 Huang, Chen, Zhang, Li, Chen, Yang (bib0330) 2018; 64 Halliwell (bib0090) 1995; 49 Vacca, Valenti, Caccamese, Daglia, Braidy, Nabavi (bib0270) 2016; 71 Kim, Shim, Ahn, Jung (bib0085) 2013; 269 Deng, Xu, Zhang, Yang, Zhang, Huang (bib0335) 2014; 10 Bavelier, Green, Pouget, Schrater (bib0215) 2012; 35 Park, Zhao, Kim, Sohn (bib0060) 2007; 559 Yu, Di, Dong, Li, Zhang, Xue (bib0140) 2018; 1864 Krenisky, Luo, Reed, Carney (bib0260) 1999; 22 Newton, Lau, Gurcha, Besra, Wright (bib0130) 2002; 79 Xin, Wang, Yang, Su, Fan, Wang (bib0045) 2010; 17 Kim, Lim, Lee, Jeong (bib0040) 2016; 21 Li (10.1016/j.phrs.2019.01.001_bib0160) 2013; 438 Yang (10.1016/j.phrs.2019.01.001_bib0295) 2017; 9 Newton (10.1016/j.phrs.2019.01.001_bib0130) 2002; 79 Chaudhuri (10.1016/j.phrs.2019.01.001_bib0245) 2014; 36 Seo (10.1016/j.phrs.2019.01.001_bib0265) 2014; 2014 Xin (10.1016/j.phrs.2019.01.001_bib0045) 2010; 17 Bavelier (10.1016/j.phrs.2019.01.001_bib0215) 2012; 35 Cui (10.1016/j.phrs.2019.01.001_bib0120) 2015; 20 Reiter (10.1016/j.phrs.2019.01.001_bib0300) 2010; 151 Ballesteros (10.1016/j.phrs.2019.01.001_bib0210) 2015; 55 Lim (10.1016/j.phrs.2019.01.001_bib0250) 2009; 101 Lim (10.1016/j.phrs.2019.01.001_bib0005) 2011; 18 Li (10.1016/j.phrs.2019.01.001_bib0125) 2016; 7 Huang (10.1016/j.phrs.2019.01.001_bib0330) 2018; 64 Ma (10.1016/j.phrs.2019.01.001_bib0285) 2018; 50 Seo (10.1016/j.phrs.2019.01.001_bib0080) 2013; 2013 Katsura (10.1016/j.phrs.2019.01.001_bib0110) 2001; 45 Lin (10.1016/j.phrs.2019.01.001_bib0180) 2016; 21 Fiorentini (10.1016/j.phrs.2019.01.001_bib0275) 2015; 2015 Ohsumi (10.1016/j.phrs.2019.01.001_bib0315) 2014; 24 Parzych (10.1016/j.phrs.2019.01.001_bib0325) 2014; 20 Yu (10.1016/j.phrs.2019.01.001_bib0240) 2014; 37 Yang (10.1016/j.phrs.2019.01.001_bib0145) 2013; 128 Xiang (10.1016/j.phrs.2019.01.001_bib0290) 2011; 3 Haraguchi (10.1016/j.phrs.2019.01.001_bib0070) 2002; 16 Price (10.1016/j.phrs.2019.01.001_bib0165) 2012; 15 Lopez-Otin (10.1016/j.phrs.2019.01.001_bib0200) 2013; 153 Yang (10.1016/j.phrs.2019.01.001_bib0150) 2013; 34 Park (10.1016/j.phrs.2019.01.001_bib0055) 2005; 71 Lv (10.1016/j.phrs.2019.01.001_bib0205) 2018; 44 Adhikari (10.1016/j.phrs.2019.01.001_bib0075) 2003; 16 Lee (10.1016/j.phrs.2019.01.001_bib0030) 2012; 78 Kim (10.1016/j.phrs.2019.01.001_bib0195) 2016; 7 Morikiri (10.1016/j.phrs.2019.01.001_bib0230) 2018; 505 Park (10.1016/j.phrs.2019.01.001_bib0060) 2007; 559 Mehta (10.1016/j.phrs.2019.01.001_bib0020) 1973; 29 Deng (10.1016/j.phrs.2019.01.001_bib0335) 2014; 10 Chopra (10.1016/j.phrs.2019.01.001_bib0010) 2013; 90 Mehta (10.1016/j.phrs.2019.01.001_bib0015) 1966; 7 Sun (10.1016/j.phrs.2019.01.001_bib0115) 1998; 61 Vacca (10.1016/j.phrs.2019.01.001_bib0270) 2016; 71 Choi (10.1016/j.phrs.2019.01.001_bib0100) 2010; 13 Feng (10.1016/j.phrs.2019.01.001_bib0050) 2016; 21 Kim (10.1016/j.phrs.2019.01.001_bib0085) 2013; 269 Lurie (10.1016/j.phrs.2019.01.001_bib0170) 2015; 21 Golan (10.1016/j.phrs.2019.01.001_bib0255) 2012; 28 Ohno (10.1016/j.phrs.2019.01.001_bib0025) 2010; 74 Kim (10.1016/j.phrs.2019.01.001_bib0040) 2016; 21 Newton (10.1016/j.phrs.2019.01.001_bib0225) 2015; 150 Lv (10.1016/j.phrs.2019.01.001_bib0185) 2017; 16 Wang (10.1016/j.phrs.2019.01.001_bib0320) 2014; 740 Krenisky (10.1016/j.phrs.2019.01.001_bib0260) 1999; 22 Limtrakul (10.1016/j.phrs.2019.01.001_bib0235) 2016; 11 Jiang (10.1016/j.phrs.2019.01.001_bib0280) 2018 Weng (10.1016/j.phrs.2019.01.001_bib0190) 2015; 417 Ferrandiz (10.1016/j.phrs.2019.01.001_bib0105) 1996; 48 Halliwell (10.1016/j.phrs.2019.01.001_bib0090) 1995; 49 Yu (10.1016/j.phrs.2019.01.001_bib0140) 2018; 1864 Xin (10.1016/j.phrs.2019.01.001_bib0310) 2017; 1863 Chen (10.1016/j.phrs.2019.01.001_bib0035) 2010; 643 Zhang (10.1016/j.phrs.2019.01.001_bib0065) 2017; 40 Sengupta (10.1016/j.phrs.2019.01.001_bib0305) 2011; 286 Haraguchi (10.1016/j.phrs.2019.01.001_bib0095) 2000; 66 Goh (10.1016/j.phrs.2019.01.001_bib0220) 2011; 2 Holthoff (10.1016/j.phrs.2019.01.001_bib0155) 2010; 80 Song (10.1016/j.phrs.2019.01.001_bib0340) 2018; 40 Ma (10.1016/j.phrs.2019.01.001_bib0175) 2017; 7 Zhou (10.1016/j.phrs.2019.01.001_bib0135) 2018; 64 |
| References_xml | – volume: 71 start-page: 865 year: 2016 end-page: 877 ident: bib0270 article-title: Plant polyphenols as natural drugs for the management of down syndrome and related disorders publication-title: Neurosci. Biobehav. Rev. – volume: 128 start-page: 2232 year: 2013 end-page: 2240 ident: bib0145 article-title: Novel role of silent information regulator 1 in myocardial ischemia publication-title: Circulation – volume: 2015 year: 2015 ident: bib0275 article-title: Polyphenols as modulators of aquaporin family in health and disease publication-title: Oxid. Med. Cell. Longev. – volume: 74 start-page: 1504 year: 2010 end-page: 1506 ident: bib0025 article-title: Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells publication-title: Biosci. Biotechnol. Biochem. – volume: 10 start-page: 1776 year: 2014 end-page: 1786 ident: bib0335 article-title: Berberine attenuates autophagy in adipocytes by targeting becn1 publication-title: Autophagy. – volume: 55 start-page: 453 year: 2015 end-page: 477 ident: bib0210 article-title: Maintaining older brain functionality: a targeted review publication-title: Neurosci. Biobehav. Rev. – volume: 40 start-page: 37 year: 2018 end-page: 47 ident: bib0340 article-title: Bavachalcone from cullen corylifolium induces apoptosis and autophagy in hepg2 cells publication-title: Phytomedicine – volume: 22 start-page: 1137 year: 1999 end-page: 1140 ident: bib0260 article-title: Isolation and antihyperglycemic activity of bakuchiol from otholobium pubescens (fabaceae), a peruvian medicinal plant used for the treatment of diabetes publication-title: Biol. Pharm. Bull. – volume: 20 start-page: 460 year: 2014 end-page: 473 ident: bib0325 article-title: An overview of autophagy: morphology, mechanism, and regulation publication-title: Antioxid. Redox Signal. – volume: 40 start-page: 351 year: 2017 end-page: 359 ident: bib0065 article-title: Bakuchiol protects against acute lung injury in septic mice publication-title: Inflammation – volume: 2013 year: 2013 ident: bib0080 article-title: Protective role of psoralea corylifolia l. Seed extract against hepatic mitochondrial dysfunction induced by oxidative stress or aging publication-title: Evid. Based Complement. Alternat. Med. – volume: 66 start-page: 569 year: 2000 end-page: 571 ident: bib0095 article-title: Inhibition of mitochondrial lipid peroxidation by bakuchiol, a meroterpene from psoralea corylifolia publication-title: Planta Med. – volume: 7 start-page: 14616 year: 2016 end-page: 14627 ident: bib0195 article-title: Bakuchiol suppresses proliferation of skin cancer cells by directly targeting hck, blk, and p38 map kinase publication-title: Oncotarget – volume: 44 start-page: 8 year: 2018 end-page: 21 ident: bib0205 article-title: Pgc-1alpha sparks the fire of neuroprotection against neurodegenerative disorders publication-title: Ageing Res. Rev. – volume: 13 start-page: 1019 year: 2010 end-page: 1023 ident: bib0100 article-title: Isolation and anti-inflammatory activity of bakuchiol from ulmus davidiana var. Japonica publication-title: J. Med. Food. – volume: 269 start-page: 109 year: 2013 end-page: 120 ident: bib0085 article-title: Protective effects of the compounds isolated from the seed of psoralea corylifolia on oxidative stress-induced retinal damage publication-title: Toxicol. Appl. Pharmacol. – volume: 7 start-page: 8091 year: 2017 ident: bib0175 article-title: Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress publication-title: Sci. Rep. – volume: 48 start-page: 975 year: 1996 end-page: 980 ident: bib0105 article-title: Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice publication-title: J. Pharm. Pharmacol. – volume: 2 start-page: 30 year: 2011 end-page: 48 ident: bib0220 article-title: Functional dedifferentiation and altered connectivity in older adults: neural accounts of cognitive aging publication-title: Aging Dis. – volume: 18 start-page: 425 year: 2011 end-page: 430 ident: bib0005 article-title: Estrogenic activities of psoralea corylifolia l. Seed extracts and main constituents publication-title: Phytomedicine – volume: 16 start-page: 8977 year: 2017 end-page: 8982 ident: bib0185 article-title: Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through pi3k/akt and mapk signaling pathways publication-title: Mol. Med. Rep. – volume: 21 start-page: 889 year: 2016 end-page: 894 ident: bib0180 article-title: Bakuchiol inhibits cell proliferation and induces apoptosis and cell cycle arrest in sgc-7901 human gastric cancer cells publication-title: J. BUON – volume: 21 start-page: 532 year: 2016 end-page: 545 ident: bib0050 article-title: Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1 publication-title: Apoptosis – volume: 90 start-page: 44 year: 2013 end-page: 56 ident: bib0010 article-title: Psoralea corylifolia l. (buguchi) - folklore to modern evidence: review publication-title: Fitoterapia – volume: 1863 start-page: 486 year: 2017 end-page: 498 ident: bib0310 article-title: Foxos in the impaired heart: new therapeutic targets for cardiac diseases publication-title: Biochim. Biophys. Acta – volume: 11 start-page: 1877 year: 2016 end-page: 1882 ident: bib0235 article-title: Inhibition of the mapk signaling pathway by red rice extract in uvb-irradiated human skin fibroblasts publication-title: Nat. Prod. Commun. – volume: 61 start-page: 362 year: 1998 end-page: 366 ident: bib0115 article-title: DNA polymerase and topoisomerase ii inhibitors from psoralea corylifolia publication-title: J. Nat. Prod. – volume: 286 start-page: 7468 year: 2011 end-page: 7478 ident: bib0305 article-title: Foxo transcription factors promote cardiomyocyte survival upon induction of oxidative stress publication-title: J. Biol. Chem. – volume: 16 start-page: 539 year: 2002 end-page: 544 ident: bib0070 article-title: Antioxidative components of psoralea corylifolia (leguminosae) publication-title: Phytother. Res. – volume: 101 start-page: 1031 year: 2009 end-page: 1039 ident: bib0250 article-title: Ethanol extract of psoralea corylifolia l. And its main constituent, bakuchiol, reduce bone loss in ovariectomised sprague-dawley rats publication-title: Br. J. Nutr. – volume: 7 start-page: 128 year: 2016 ident: bib0125 article-title: Phytoestrogen bakuchiol exhibits in vitro and in vivo anti-breast cancer effects by inducing s phase arrest and apoptosis publication-title: Front. Pharmacol. – volume: 151 start-page: 103 year: 2010 end-page: 114 ident: bib0300 article-title: Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for amp-activated protein kinase, akt, and foxo1 publication-title: Endocrinology – volume: 3 start-page: 1098 year: 2011 end-page: 1109 ident: bib0290 article-title: Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the foxo forkhead transcription factor publication-title: Aging (Albany NY) – volume: 79 start-page: 57 year: 2002 end-page: 67 ident: bib0130 article-title: The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from psoralea corylifolia and sanguinaria canadensis publication-title: J. Ethnopharmacol. – volume: 28 start-page: 131 year: 2012 end-page: 137 ident: bib0255 article-title: Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control publication-title: Nutrition – volume: 7 start-page: 4561 year: 1966 end-page: 4567 ident: bib0015 article-title: Bakuchiol, a novel monoterpenoid publication-title: Tetrahedron Lett. – volume: 505 start-page: 1168 year: 2018 end-page: 1173 ident: bib0230 article-title: The collagen-derived compound collagen tripeptide induces collagen expression and extends lifespan via a conserved p38 mitogen-activated protein kinase cascade publication-title: Biochem. Biophys. Res. Commun. – volume: 78 start-page: 903 year: 2012 end-page: 906 ident: bib0030 article-title: Phenolic compounds isolated from psoralea corylifolia inhibit il-6-induced stat3 activation publication-title: Planta Med. – volume: 64 year: 2018 ident: bib0135 article-title: Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy publication-title: J. Pineal Res. – volume: 559 start-page: 115 year: 2007 end-page: 123 ident: bib0060 article-title: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-jun nh2-terminal kinase-mediated mitochondrial translocation of bax in rat liver myofibroblasts publication-title: Eur. J. Pharmacol. – volume: 2014 year: 2014 ident: bib0265 article-title: Psoralea corylifolia l. Seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress publication-title: Oxid. Med. Cell. Longev. – volume: 34 start-page: 2879 year: 2013 end-page: 2888 ident: bib0150 article-title: New role of silent information regulator 1 in cerebral ischemia publication-title: Neurobiol. Aging – volume: 15 start-page: 675 year: 2012 end-page: 690 ident: bib0165 article-title: Sirt1 is required for ampk activation and the beneficial effects of resveratrol on mitochondrial function publication-title: Cell Metab. – volume: 150 start-page: 665 year: 2015 end-page: 674 ident: bib0225 article-title: Skin aging: molecular pathology, dermal remodelling and the imaging revolution publication-title: G. Ital. Dermatol. Venereol. – volume: 36 start-page: 221 year: 2014 end-page: 230 ident: bib0245 article-title: Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects publication-title: Int. J. Cosmet. Sci. – volume: 21 year: 2016 ident: bib0040 article-title: Quantitative analysis of psoralea corylifolia linne and its neuroprotective and anti-neuroinflammatory effects in ht22 hippocampal cells and bv-2 microglia publication-title: Molecules – volume: 35 start-page: 391 year: 2012 end-page: 416 ident: bib0215 article-title: Brain plasticity through the life span: learning to learn and action video games publication-title: Annu. Rev. Neurosci. – volume: 24 start-page: 9 year: 2014 end-page: 23 ident: bib0315 article-title: Historical landmarks of autophagy research publication-title: Cell Res. – volume: 20 start-page: 12500 year: 2015 end-page: 12511 ident: bib0120 article-title: Constituents of psoralea corylifolia fruits and their effects on methicillin-resistant staphylococcus aureus publication-title: Molecules – volume: 438 start-page: 270 year: 2013 end-page: 276 ident: bib0160 article-title: Resveratrol protects cardiomyocytes from oxidative stress through sirt1 and mitochondrial biogenesis signaling pathways publication-title: Biochem. Biophys. Res. Commun. – volume: 153 start-page: 1194 year: 2013 end-page: 1217 ident: bib0200 article-title: The hallmarks of aging publication-title: Cell – volume: 64 start-page: 129 year: 2018 end-page: 139 ident: bib0330 article-title: Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation publication-title: J. Mol. Neurosci. – volume: 740 start-page: 312 year: 2014 end-page: 320 ident: bib0320 article-title: Downregulation of pi3k/akt/mtor signaling pathway in curcumin-induced autophagy in app/ps1 double transgenic mice publication-title: Eur. J. Pharmacol. – volume: 29 start-page: 1119 year: 1973 end-page: 1125 ident: bib0020 article-title: Meroterpenoids: psoralea corylifolid linn-1 bakuchiol, a novel monoterpenoid publication-title: Tetrahedron – volume: 71 start-page: 508 year: 2005 end-page: 513 ident: bib0055 article-title: Protective effect of (s)-bakuchiol from psoralea corylifolia on rat liver injury in vitro and in vivo publication-title: Planta Med. – volume: 17 start-page: 126 year: 2010 end-page: 131 ident: bib0045 article-title: Phytoestrogens from psoralea corylifolia reveal estrogen receptor-subtype selectivity publication-title: Phytomedicine – volume: 50 start-page: 21 year: 2018 end-page: 31 ident: bib0285 article-title: Forkhead box o proteins: crucial regulators of cancer emt publication-title: Semin. Cancer Biol. – volume: 643 start-page: 170 year: 2010 end-page: 179 ident: bib0035 article-title: Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma a549 cell line publication-title: Eur. J. Pharmacol. – volume: 417 start-page: 103 year: 2015 end-page: 113 ident: bib0190 article-title: Positive skeletal effect of two ingredients of psoralea corylifolia l. On estrogen deficiency-induced osteoporosis and the possible mechanisms of action publication-title: Mol. Cell. Endocrinol. – volume: 80 start-page: 1260 year: 2010 end-page: 1265 ident: bib0155 article-title: Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite publication-title: Biochem. Pharmacol. – year: 2018 ident: bib0280 article-title: Deciphering the roles of foxo1 in human neoplasms publication-title: Int. J. Cancer – volume: 21 start-page: 11567 year: 2015 end-page: 11583 ident: bib0170 article-title: Non-invasive diagnosis of liver fibrosis and cirrhosis publication-title: World J. Gastroenterol. – volume: 37 start-page: 632 year: 2014 end-page: 635 ident: bib0240 article-title: [Regulative effect of bakuchiol on esf-1 cells anti-aging gene] publication-title: Zhong Yao Cai – volume: 49 start-page: 1341 year: 1995 end-page: 1348 ident: bib0090 article-title: Antioxidant characterization. Methodology and mechanism publication-title: Biochem. Pharmacol. – volume: 45 start-page: 3009 year: 2001 end-page: 3013 ident: bib0110 article-title: In vitro antimicrobial activities of bakuchiol against oral microorganisms publication-title: Antimicrob. Agents Chemother. – volume: 9 start-page: 797 year: 2017 end-page: 816 ident: bib0295 article-title: Foxc1 in cancer development and therapy: deciphering its emerging and divergent roles publication-title: Ther. Adv. Med. Oncol. – volume: 16 start-page: 1062 year: 2003 end-page: 1069 ident: bib0075 article-title: Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain publication-title: Chem. Res. Toxicol. – volume: 1864 start-page: 563 year: 2018 end-page: 578 ident: bib0140 article-title: Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cgmp-pkg activation publication-title: Biochim. Biophys. Acta Mol. Basis Dis. – volume: 643 start-page: 170 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0035 article-title: Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma a549 cell line publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.06.025 – volume: 44 start-page: 8 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0205 article-title: Pgc-1alpha sparks the fire of neuroprotection against neurodegenerative disorders publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2018.03.004 – volume: 438 start-page: 270 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0160 article-title: Resveratrol protects cardiomyocytes from oxidative stress through sirt1 and mitochondrial biogenesis signaling pathways publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2013.07.042 – volume: 16 start-page: 539 year: 2002 ident: 10.1016/j.phrs.2019.01.001_bib0070 article-title: Antioxidative components of psoralea corylifolia (leguminosae) publication-title: Phytother. Res. doi: 10.1002/ptr.972 – volume: 740 start-page: 312 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0320 article-title: Downregulation of pi3k/akt/mtor signaling pathway in curcumin-induced autophagy in app/ps1 double transgenic mice publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2014.06.051 – volume: 2014 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0265 article-title: Psoralea corylifolia l. Seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2014/897296 – volume: 11 start-page: 1877 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0235 article-title: Inhibition of the mapk signaling pathway by red rice extract in uvb-irradiated human skin fibroblasts publication-title: Nat. Prod. Commun. – volume: 71 start-page: 508 year: 2005 ident: 10.1016/j.phrs.2019.01.001_bib0055 article-title: Protective effect of (s)-bakuchiol from psoralea corylifolia on rat liver injury in vitro and in vivo publication-title: Planta Med. doi: 10.1055/s-2005-864150 – volume: 2015 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0275 article-title: Polyphenols as modulators of aquaporin family in health and disease publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2015/196914 – volume: 20 start-page: 460 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0325 article-title: An overview of autophagy: morphology, mechanism, and regulation publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2013.5371 – volume: 128 start-page: 2232 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0145 article-title: Novel role of silent information regulator 1 in myocardial ischemia publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.002480 – volume: 74 start-page: 1504 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0025 article-title: Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.100221 – volume: 2013 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0080 article-title: Protective role of psoralea corylifolia l. Seed extract against hepatic mitochondrial dysfunction induced by oxidative stress or aging publication-title: Evid. Based Complement. Alternat. Med. doi: 10.1155/2013/678028 – volume: 24 start-page: 9 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0315 article-title: Historical landmarks of autophagy research publication-title: Cell Res. doi: 10.1038/cr.2013.169 – volume: 16 start-page: 1062 year: 2003 ident: 10.1016/j.phrs.2019.01.001_bib0075 article-title: Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain publication-title: Chem. Res. Toxicol. doi: 10.1021/tx034082r – volume: 48 start-page: 975 year: 1996 ident: 10.1016/j.phrs.2019.01.001_bib0105 article-title: Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1996.tb06016.x – volume: 55 start-page: 453 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0210 article-title: Maintaining older brain functionality: a targeted review publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2015.06.008 – volume: 40 start-page: 37 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0340 article-title: Bavachalcone from cullen corylifolium induces apoptosis and autophagy in hepg2 cells publication-title: Phytomedicine doi: 10.1016/j.phymed.2017.12.030 – volume: 7 start-page: 128 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0125 article-title: Phytoestrogen bakuchiol exhibits in vitro and in vivo anti-breast cancer effects by inducing s phase arrest and apoptosis publication-title: Front. Pharmacol. doi: 10.3389/fphar.2016.00128 – volume: 150 start-page: 665 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0225 article-title: Skin aging: molecular pathology, dermal remodelling and the imaging revolution publication-title: G. Ital. Dermatol. Venereol. – volume: 34 start-page: 2879 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0150 article-title: New role of silent information regulator 1 in cerebral ischemia publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2013.06.008 – year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0280 article-title: Deciphering the roles of foxo1 in human neoplasms publication-title: Int. J. Cancer doi: 10.1002/ijc.31338 – volume: 50 start-page: 21 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0285 article-title: Forkhead box o proteins: crucial regulators of cancer emt publication-title: Semin. Cancer Biol. doi: 10.1016/j.semcancer.2018.02.004 – volume: 37 start-page: 632 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0240 article-title: [Regulative effect of bakuchiol on esf-1 cells anti-aging gene] publication-title: Zhong Yao Cai – volume: 29 start-page: 1119 year: 1973 ident: 10.1016/j.phrs.2019.01.001_bib0020 article-title: Meroterpenoids: psoralea corylifolid linn-1 bakuchiol, a novel monoterpenoid publication-title: Tetrahedron doi: 10.1016/0040-4020(73)80071-7 – volume: 16 start-page: 8977 year: 2017 ident: 10.1016/j.phrs.2019.01.001_bib0185 article-title: Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through pi3k/akt and mapk signaling pathways publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2017.7696 – volume: 61 start-page: 362 year: 1998 ident: 10.1016/j.phrs.2019.01.001_bib0115 article-title: DNA polymerase and topoisomerase ii inhibitors from psoralea corylifolia publication-title: J. Nat. Prod. doi: 10.1021/np970488q – volume: 151 start-page: 103 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0300 article-title: Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for amp-activated protein kinase, akt, and foxo1 publication-title: Endocrinology doi: 10.1210/en.2009-0997 – volume: 3 start-page: 1098 year: 2011 ident: 10.1016/j.phrs.2019.01.001_bib0290 article-title: Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the foxo forkhead transcription factor publication-title: Aging (Albany NY) doi: 10.18632/aging.100396 – volume: 64 start-page: 129 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0330 article-title: Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-017-1006-x – volume: 17 start-page: 126 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0045 article-title: Phytoestrogens from psoralea corylifolia reveal estrogen receptor-subtype selectivity publication-title: Phytomedicine doi: 10.1016/j.phymed.2009.05.015 – volume: 13 start-page: 1019 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0100 article-title: Isolation and anti-inflammatory activity of bakuchiol from ulmus davidiana var. Japonica publication-title: J. Med. Food. doi: 10.1089/jmf.2009.1207 – volume: 80 start-page: 1260 year: 2010 ident: 10.1016/j.phrs.2019.01.001_bib0155 article-title: Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2010.06.027 – volume: 35 start-page: 391 year: 2012 ident: 10.1016/j.phrs.2019.01.001_bib0215 article-title: Brain plasticity through the life span: learning to learn and action video games publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev-neuro-060909-152832 – volume: 45 start-page: 3009 year: 2001 ident: 10.1016/j.phrs.2019.01.001_bib0110 article-title: In vitro antimicrobial activities of bakuchiol against oral microorganisms publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.45.11.3009-3013.2001 – volume: 559 start-page: 115 year: 2007 ident: 10.1016/j.phrs.2019.01.001_bib0060 article-title: Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-jun nh2-terminal kinase-mediated mitochondrial translocation of bax in rat liver myofibroblasts publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2007.01.024 – volume: 153 start-page: 1194 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0200 article-title: The hallmarks of aging publication-title: Cell doi: 10.1016/j.cell.2013.05.039 – volume: 286 start-page: 7468 year: 2011 ident: 10.1016/j.phrs.2019.01.001_bib0305 article-title: Foxo transcription factors promote cardiomyocyte survival upon induction of oxidative stress publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.179242 – volume: 505 start-page: 1168 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0230 article-title: The collagen-derived compound collagen tripeptide induces collagen expression and extends lifespan via a conserved p38 mitogen-activated protein kinase cascade publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2018.10.044 – volume: 7 start-page: 14616 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0195 article-title: Bakuchiol suppresses proliferation of skin cancer cells by directly targeting hck, blk, and p38 map kinase publication-title: Oncotarget doi: 10.18632/oncotarget.7524 – volume: 78 start-page: 903 year: 2012 ident: 10.1016/j.phrs.2019.01.001_bib0030 article-title: Phenolic compounds isolated from psoralea corylifolia inhibit il-6-induced stat3 activation publication-title: Planta Med. doi: 10.1055/s-0031-1298482 – volume: 9 start-page: 797 year: 2017 ident: 10.1016/j.phrs.2019.01.001_bib0295 article-title: Foxc1 in cancer development and therapy: deciphering its emerging and divergent roles publication-title: Ther. Adv. Med. Oncol. doi: 10.1177/1758834017742576 – volume: 2 start-page: 30 year: 2011 ident: 10.1016/j.phrs.2019.01.001_bib0220 article-title: Functional dedifferentiation and altered connectivity in older adults: neural accounts of cognitive aging publication-title: Aging Dis. – volume: 21 start-page: 11567 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0170 article-title: Non-invasive diagnosis of liver fibrosis and cirrhosis publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v21.i41.11567 – volume: 21 start-page: 889 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0180 article-title: Bakuchiol inhibits cell proliferation and induces apoptosis and cell cycle arrest in sgc-7901 human gastric cancer cells publication-title: J. BUON – volume: 417 start-page: 103 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0190 article-title: Positive skeletal effect of two ingredients of psoralea corylifolia l. On estrogen deficiency-induced osteoporosis and the possible mechanisms of action publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2015.09.025 – volume: 36 start-page: 221 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0245 article-title: Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects publication-title: Int. J. Cosmet. Sci. doi: 10.1111/ics.12117 – volume: 90 start-page: 44 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0010 article-title: Psoralea corylifolia l. (buguchi) - folklore to modern evidence: review publication-title: Fitoterapia doi: 10.1016/j.fitote.2013.06.016 – volume: 71 start-page: 865 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0270 article-title: Plant polyphenols as natural drugs for the management of down syndrome and related disorders publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2016.10.023 – volume: 79 start-page: 57 year: 2002 ident: 10.1016/j.phrs.2019.01.001_bib0130 article-title: The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from psoralea corylifolia and sanguinaria canadensis publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(01)00350-6 – volume: 18 start-page: 425 year: 2011 ident: 10.1016/j.phrs.2019.01.001_bib0005 article-title: Estrogenic activities of psoralea corylifolia l. Seed extracts and main constituents publication-title: Phytomedicine doi: 10.1016/j.phymed.2011.02.002 – volume: 28 start-page: 131 year: 2012 ident: 10.1016/j.phrs.2019.01.001_bib0255 article-title: Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control publication-title: Nutrition doi: 10.1016/j.nut.2011.04.001 – volume: 49 start-page: 1341 year: 1995 ident: 10.1016/j.phrs.2019.01.001_bib0090 article-title: Antioxidant characterization. Methodology and mechanism publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(95)00088-H – volume: 20 start-page: 12500 year: 2015 ident: 10.1016/j.phrs.2019.01.001_bib0120 article-title: Constituents of psoralea corylifolia fruits and their effects on methicillin-resistant staphylococcus aureus publication-title: Molecules doi: 10.3390/molecules200712500 – volume: 21 start-page: 532 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0050 article-title: Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1 publication-title: Apoptosis doi: 10.1007/s10495-016-1225-6 – volume: 66 start-page: 569 year: 2000 ident: 10.1016/j.phrs.2019.01.001_bib0095 article-title: Inhibition of mitochondrial lipid peroxidation by bakuchiol, a meroterpene from psoralea corylifolia publication-title: Planta Med. doi: 10.1055/s-2000-8605 – volume: 1864 start-page: 563 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0140 article-title: Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cgmp-pkg activation publication-title: Biochim. Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2017.11.023 – volume: 269 start-page: 109 year: 2013 ident: 10.1016/j.phrs.2019.01.001_bib0085 article-title: Protective effects of the compounds isolated from the seed of psoralea corylifolia on oxidative stress-induced retinal damage publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2013.03.017 – volume: 64 year: 2018 ident: 10.1016/j.phrs.2019.01.001_bib0135 article-title: Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy publication-title: J. Pineal Res. doi: 10.1111/jpi.12471 – volume: 40 start-page: 351 year: 2017 ident: 10.1016/j.phrs.2019.01.001_bib0065 article-title: Bakuchiol protects against acute lung injury in septic mice publication-title: Inflammation doi: 10.1007/s10753-016-0481-5 – volume: 7 start-page: 8091 year: 2017 ident: 10.1016/j.phrs.2019.01.001_bib0175 article-title: Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress publication-title: Sci. Rep. doi: 10.1038/s41598-017-08547-0 – volume: 7 start-page: 4561 year: 1966 ident: 10.1016/j.phrs.2019.01.001_bib0015 article-title: Bakuchiol, a novel monoterpenoid publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)70078-5 – volume: 21 year: 2016 ident: 10.1016/j.phrs.2019.01.001_bib0040 article-title: Quantitative analysis of psoralea corylifolia linne and its neuroprotective and anti-neuroinflammatory effects in ht22 hippocampal cells and bv-2 microglia publication-title: Molecules doi: 10.3390/molecules21081076 – volume: 15 start-page: 675 year: 2012 ident: 10.1016/j.phrs.2019.01.001_bib0165 article-title: Sirt1 is required for ampk activation and the beneficial effects of resveratrol on mitochondrial function publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.04.003 – volume: 22 start-page: 1137 year: 1999 ident: 10.1016/j.phrs.2019.01.001_bib0260 article-title: Isolation and antihyperglycemic activity of bakuchiol from otholobium pubescens (fabaceae), a peruvian medicinal plant used for the treatment of diabetes publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.22.1137 – volume: 101 start-page: 1031 year: 2009 ident: 10.1016/j.phrs.2019.01.001_bib0250 article-title: Ethanol extract of psoralea corylifolia l. And its main constituent, bakuchiol, reduce bone loss in ovariectomised sprague-dawley rats publication-title: Br. J. Nutr. doi: 10.1017/S0007114508066750 – volume: 1863 start-page: 486 year: 2017 ident: 10.1016/j.phrs.2019.01.001_bib0310 article-title: Foxos in the impaired heart: new therapeutic targets for cardiac diseases publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2016.11.023 – volume: 10 start-page: 1776 year: 2014 ident: 10.1016/j.phrs.2019.01.001_bib0335 article-title: Berberine attenuates autophagy in adipocytes by targeting becn1 publication-title: Autophagy. doi: 10.4161/auto.29746 |
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Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of... Bakuchiol (BAK), [(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol is a prenylated phenolic monoterpene extracted from the fruit of Psoralea corylifolia... |
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| Title | Bakuchiol: A newly discovered warrior against organ damage |
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