Genetic variability in E6, E7, and L1 genes of human papillomavirus genotype 52 from Southwest China

• Published in: Gene Vol. 585; no. 1; pp. 110 - 118
• Main Authors: Zhang, Yiwen, Cao, Man, Wang, Mengting, Ding, Xianping, Jing, Yaling, Chen, Zuyi, Ma, Tengjiao, Chen, Honghan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2016
• Subjects: Alphapapillomavirus - genetics; Amino Acid Sequence; Base Sequence; China; DNA, Viral - genetics; Female; genes; genetic databases; genetic variation; genotype; HPV-52; Human papillomavirus; Humans; Molecular Sequence Data; mutation; Mutations; Oncogene Proteins, Viral - genetics; Papillomaviridae; Phylogenetic analysis; phylogeny; Polymorphism, Single Nucleotide - genetics; Polymorphisms; risk; Sequence Analysis, DNA; uterine cervical neoplasms; Uterine Cervical Neoplasms - virology; vaccine development; Variants; women; China; HPV-52; Phylogenetic analysis; Mutations; Variants; ORF; Polymorphisms; BEB; HPV

Human papillomavirus (HPV) is the major causative agent of cervical cancer, which accounts for the second highest cancer burden in women worldwide. HPV-52, the prevalent subtype in Asia, especially in southwest China, was analyzed in this study. To analyze polymorphisms, intratypic variants, and gen...