A systems immunology perspective on gout pathogenesis and its precision-targeted treatment strategies

• Published in: Frontiers in immunology Vol. 16; p. 1615914
• Main Authors: Chen, Zilong, Guo, Qian, Zhang, Yanzhao, Chen, Lulu, Li, Puyu, Cheng, Wenfei, Liu, Chuanxin, Jiang, Hongwei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.06.2025
• Subjects: Adaptive Immunity; Animals; autoimmune; Autophagy; Biomarkers; cytokine; Epigenesis, Genetic; Gout - drug therapy; Gout - immunology; gouty arthritis; Humans; Immunity, Innate; Immunology; immunotherapy; Microbiota; monosodium urate crystals; cytokine; autophagy; autoimmune; gouty arthritis; monosodium urate crystals; immunotherapy

Gouty arthritis (GA) is a sterile inflammatory disease driven by monosodium urate (MSU) crystal deposition, which activates innate and adaptive immune responses. Key mechanisms involve NLRP3 inflammasome activation, cytokine release (IL-1β, TNF-α, IL-6), and dysregulated autophagy, positioning GA at...