Dynamic stem cell heterogeneity

• Published in: Development (Cambridge) Vol. 142; no. 8; pp. 1396 - 1406
• Main Authors: Krieger, Teresa, Simons, Benjamin D.
• Format: Journal Article
• Language: English
• Published: England 15.04.2015
• Subjects: Adult Stem Cells - cytology; Adult Stem Cells - metabolism; Animals; Cell Lineage; Female; Humans; Intestines - cytology; Male; Spermatogenesis - physiology; Stem Cells - cytology; Stem Cells - metabolism; Gene heterogeneity; Tissue homeostasis; Adult stem cell; Intestine; Lineage tracing; Germ line

Recent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues. These studies have revealed that stem cells are frequently lost through differentiation and that this is compensated for...