Ornithine decarboxylase antizyme 2 (OAZ2) in human colon adenocarcinoma: a potent prognostic factor associated with immunity

• Published in: Scientific reports Vol. 15; no. 1; pp. 7481 - 13
• Main Authors: Liu, Yiheng, Zhang, Shengjie, Liao, Wenjie, Qian, Jun, Lu, Cuihua, Jin, Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/337; 631/45; 631/67; 631/80; 692/4028; 692/53; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - immunology; Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cardiac muscle; Cell Line, Tumor; Cell Proliferation; COAD; Colonic Neoplasms - genetics; Colonic Neoplasms - immunology; Colonic Neoplasms - metabolism; Colonic Neoplasms - mortality; Colonic Neoplasms - pathology; Colorectal cancer; Colorectal carcinoma; Female; Gene Expression Regulation, Neoplastic; Gene set enrichment analysis; Humanities and Social Sciences; Humans; Immunity; Immunomodulation; Male; Metastases; Microsatellite instability; Middle Aged; mRNA; multidisciplinary; Muscle contraction; OAZ2; Ornithine decarboxylase; Overall survival; Oxidative phosphorylation; Phosphorylation; Prognosis; Regression analysis; Science; Science (multidisciplinary); Tumor microenvironment; Tumors; COAD; Prognosis; Overall survival; Immunity; OAZ2

Despite few studies focusing on the OAZ2 gene in colorectal cancer, its potential role in colon adenocarcinoma (COAD) prognosis and immune modulation remains underexplored. This study examines the expression and mechanistic involvement of OAZ2 in COAD using data from The Cancer Genome Atlas (TCGA) a...