H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases

• Published in: Frontiers in immunology Vol. 16; p. 1572796
• Main Authors: Han, Lingli, Li, Lin, Yao, Liangjiao, Bu, Huaqin, Tian, Yajie, Li, Qifan, Zhu, Ke, Yao, Haili, Wang, Xiaochuan, Qian, Maoxiang, Lu, Wei, Sun, Jinqiao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.05.2025
• Subjects: Animals; Child; Disease Models, Animal; Epigenesis, Genetic; Female; H3K27me3; HDM; Histones - immunology; Histones - metabolism; Humans; Hypersensitivity - immunology; Immunity, Innate; Immunologic Memory; Immunology; inflammation; KDM6B; Male; Methylation; Mice; monocytes; Monocytes - immunology; Monocytes - metabolism; Pyroglyphidae - immunology; Trained Immunity; HDM; KDM6B; monocytes; inflammation; H3K27me3

Monocytes have been confirmed to increase in persistently food-allergic children. A phenomenon of innate immune memory, called trained immunity, has also been observed in monocytes from allergic children. However, the underlying mechanism remains poorly understood. We enrolled a cohort of HDM-allerg...