Advancements and challenges in immunotherapy for gastric cancer: current approaches and future directions

• Published in: Frontiers in immunology Vol. 16; p. 1592733
• Main Authors: Zhang, Wenyu, Chen, Jingzheng, Wei, Zehao, Song, Jiaqian, Zha, Xinyi, Wang, Deqiang, Xu, Min
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.05.2025
• Subjects: adoptive cell therapy; Animals; Cancer Vaccines - immunology; Cancer Vaccines - therapeutic use; Combined Modality Therapy; gastric cancer; Humans; immune checkpoint inhibitors; Immune Checkpoint Inhibitors - therapeutic use; Immunology; immunotherapy; Immunotherapy - methods; Immunotherapy - trends; Immunotherapy, Adoptive - methods; Stomach Neoplasms - immunology; Stomach Neoplasms - therapy; tumor microenvironment; Tumor Microenvironment - immunology; tumor vaccines; gastric cancer; tumor vaccines; immunotherapy; immune checkpoint inhibitors; tumor microenvironment; oncolytic viruses; adoptive cell therapy

Gastric cancer (GC) poses a major global health challenge, marked by high incidence and mortality rates. Conventional treatments such as surgery, chemotherapy, and targeted therapies show limited effectiveness in patients at advanced stages. As a result, immunotherapy has emerged as a promising stra...