Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway

• Published in: Experimental gerontology Vol. 204; p. 112743
• Main Authors: Wu, Yating, Li, Fengrui, Shu, Shibin, Feng, Zhenhua, Qiu, Yong, Li, Sen, Zhu, Zezhang
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2025; Elsevier
• Subjects: Animals; Baicalin; Cells, Cultured; Disease Models, Animal; Extracellular matrix; Flavonoids - pharmacology; Inflammation; Interleukin-1beta - pharmacology; Intervertebral disc degeneration; Intervertebral Disc Degeneration - drug therapy; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Male; MAP Kinase Signaling System - drug effects; Mice; Mice, Inbred C57BL; Nucleus Pulposus - drug effects; Nucleus Pulposus - metabolism; Nucleus Pulposus - pathology; Nucleus pulposus cells; p38 Mitogen-Activated Protein Kinases - metabolism; Signal Transduction - drug effects; Intervertebral disc degeneration; Extracellular matrix; Inflammation; Baicalin; Nucleus pulposus cells

Intervertebral disc degeneration (IVDD) represents a prevalent degenerative pathology of the spinal, primarily precipitated by inflammatory processes and the deterioration of extracellular matrix (ECM). Baicalin has an effective anti-inflammatory effect on degenerative diseases. In addition, the P38...