The role of P2X4 receptor in neuropathic pain and its pharmacological properties

• Published in: Pharmacological research Vol. 158; p. 104875
• Main Authors: Zhang, Wen-Jun, Zhu, Zheng-Ming, Liu, Zeng-Xu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2020
• Subjects: Antagonists; ATP; Nerve system; NPP; P2X4R; PCNA; KCC2; JNK; Antagonists; CXCL5; AsODN; NPP; CAMKII; PANX1; NF-xB; NMDA; NLRP3; Tumor; BzATP; BDNF; BDNF-TrkB; PKC; P2X4R; MAPK; IL-1β; IL-6; Nerve system; NALP3; IL-18; ATK; GABA; MEK1; ATP; MMP-9; TLR4; ERK

The activation of P2×4R activates microglia, opens the ion channels on the cell membrane (mainly calcium influx), activates intracellular related signal pathways in microglia (such as AKT, JNK), releases various injurious factors (such as TNF-a, IL-18, IL-10), induces and promotes nerve cell damage...