The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy

• Published in: Cancer research (Chicago, Ill.) Vol. 81; no. 19; pp. 4926 - 4938
• Main Authors: Hirata, Hidenari, Niida, Atsushi, Kakiuchi, Nobuyuki, Uchi, Ryutaro, Sugimachi, Keishi, Masuda, Takaaki, Saito, Tomoko, Kageyama, Shun-Ichiro, Motomura, Yushi, Ito, Shuhei, Yoshitake, Tadamasa, Tsurumaru, Daisuke, Nishimuta, Yusuke, Yokoyama, Akira, Hasegawa, Takanori, Chiba, Kenichi, Shiraishi, Yuichi, Du, Junyan, Miura, Fumihito, Morita, Masaru, Toh, Yasushi, Hirakawa, Masakazu, Shioyama, Yoshiyuki, Ito, Takashi, Akimoto, Tetsuo, Miyano, Satoru, Shibata, Tatsuhiro, Mori, Masaki, Suzuki, Yutaka, Ogawa, Seishi, Ishigami, Kousei, Mimori, Koshi
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Biomarkers, Tumor; Chemoradiotherapy; Clonal Evolution - drug effects; Clonal Evolution - genetics; Clonal Evolution - radiation effects; Computational Biology - methods; Databases, Genetic; Disease Management; Drug Resistance, Neoplasm - genetics; Esophageal Squamous Cell Carcinoma - diagnosis; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - therapy; Evolution, Molecular; Genetic Predisposition to Disease; Genomics - methods; Humans; INDEL Mutation; Mutation; Neoplasm Recurrence, Local; Neoplasm Staging; Polymorphism, Single Nucleotide; Prognosis; Radiation Tolerance - genetics; Tumor Burden; Whole Exome Sequencing

Esophageal squamous cell carcinoma (ESCC) often recurs after chemoradiotherapy, and the prognosis of ESCC after chemoradiotherapy has not improved over the past few decades. The mutation process in chemoradiotherapy-resistant clones and the functional relevance of genetic alterations remain unclear....