The challenges of liver transplantation in children with primary sclerosing cholangitis

• Published in: Expert review of gastroenterology & hepatology Vol. 9; no. 3; p. 289
• Main Authors: Venkat, Veena L, Ranganathan, Sarangarajan, Sindhi, Rakesh
• Format: Journal Article
• Language: English
• Published: England 01.03.2015
• Subjects: Autoimmune Diseases - complications; Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; Autoimmune Diseases - surgery; Child; Child, Preschool; Cholangitis, Sclerosing - complications; Cholangitis, Sclerosing - genetics; Cholangitis, Sclerosing - immunology; Cholangitis, Sclerosing - surgery; End Stage Liver Disease - etiology; End Stage Liver Disease - surgery; Genetic Predisposition to Disease; Hepatitis, Autoimmune - complications; Humans; Infant; Inflammatory Bowel Diseases - complications; Liver Transplantation; Recurrence; Treatment Outcome; PSC; transplant outcome; autoimmune liver disease; children; liver transplant

Primary sclerosing cholangitis (PSC) in children can progress to end-stage liver disease requiring liver transplantation. PSC poses many challenges beginning with evaluation and classification of ductal involvement and overlap syndromes, few options for medical management and unique risks in the pos...