Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms

• Published in: Pharmacological research Vol. 183; p. 106364
• Main Authors: Liu, Chunping, He, Dongyue, Li, Longmei, Zhang, Shihui, Wang, Lei, Fan, Zhijin, Wang, Yichao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2022; Elsevier
• Subjects: Cancer immunotherapy; Exosomes; Extracellular Vesicles; Humans; Immune escape; Immunotherapy; Microenvironment; Neoplasms - pathology; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - therapy; Tumor Escape; Tumor immune; Tumor Microenvironment; Pancreatic cancer; Extracellular vesicles; Tumor immune; Microenvironment; Exosomes; Cancer immunotherapy; Immune escape

Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis and limited treatment options. Despite great progress in clinical trials of immunotherapies for various cancers, their effectiveness in PC is very low, indicating that immune evasion is still a major obstacle...