Berberine inhibits the tarO gene to impact MRSA cell wall synthesis

• Published in: Scientific reports Vol. 15; no. 1; pp. 6927 - 12
• Main Authors: Gu, Xuemei, Zhou, Fangfang, Jiang, Mingming, Lin, Ming, Dai, Yue, Wang, Wei, Xiong, Zhongbo, Liu, Han, Xu, Minyi, Wang, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326; 631/337/2019; 631/449; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibiotics; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Berberine; Berberine - pharmacology; Biosynthesis; Cell wall; Cell Wall - drug effects; Cell Wall - metabolism; Cell walls; Drug resistance; Enzymes; Gene Expression Regulation, Bacterial - drug effects; Herbal medicine; Humanities and Social Sciences; Humans; Inhibitory mechanism; Lytic enzymes; Methicillin; Methicillin-resistant Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - metabolism; Microbial Sensitivity Tests; multidisciplinary; Multidrug resistance; Natural products; Oxacillin; Penicillin; Peptidoglycan - metabolism; Peptidoglycans; Public health; Science; Science (multidisciplinary); Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus infections; tarO; Teichoic Acids - biosynthesis; Traditional Chinese medicine; Inhibitory mechanism; Berberine; Methicillin-resistant; Cell wall; tarO; Methicillin-resistant Staphylococcus aureus

Hospital and community-acquired infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) have emerged as a significant public health challenge, highlighting the urgent need for novel antibiotics. In response, the antibacterial properties of natural products derived from traditional pl...