Berberine inhibits the tarO gene to impact MRSA cell wall synthesis - Gu, Xuemei; Zhou, Fangfang; Jiang, Mingming; Lin, Ming; Dai, Yue; Wang, Wei; Xiong, Zhongbo; Liu, Han; Xu, Minyi; Wang, Lei (Scientific reports, 2025)
Keywords: 631/326; 631/337/2019; 631/449; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibiotics; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Berberine; Berberine - pharmacology; Biosynthesis; Cell wall; Cell Wall - drug effects; Cell Wall - metabolism; Cell walls; Drug resistance; Enzymes; Gene Expression Regulation, Bacterial - drug effects; Herbal medicine; Humanities and Social Sciences; Humans; Inhibitory mechanism; Lytic enzymes; Methicillin; Methicillin-resistant Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - metabolism; Microbial Sensitivity Tests; multidisciplinary; Multidrug resistance; Natural products; Oxacillin; Penicillin; Peptidoglycan - metabolism; Peptidoglycans; Public health; Science; Science (multidisciplinary); Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus infections; tarO; Teichoic Acids - biosynthesis; Traditional Chinese medicine; Inhibitory mechanism; Berberine; Methicillin-resistant; Cell wall; tarO; Methicillin-resistant Staphylococcus aureus