The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways

• Published in: Frontiers in cellular and infection microbiology Vol. 15; p. 1603124
• Main Authors: Hsu, Chao-Yu, Li, Jyun-Yi, Huang, Wei-Ru, Liao, Tsai-Ling, Wen, Hsiao-Wei, Wang, Chi-Young, Lye, Lon-Fye, Nielsen, Brent L., Liu, Hung-Jen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.06.2025
• Subjects: A549 Cells; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Cell Line, Tumor; Cell Movement - drug effects; Cellular and Infection Microbiology; HeLa Cells; Humans; invadopodia formation; oncolytic avian reovirus; Oncolytic Viruses - genetics; Orthoreovirus, Avian - genetics; Orthoreovirus, Avian - metabolism; p17; p53-PTEN-FAK-Src; Podosomes - metabolism; Podosomes - virology; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Signal Transduction; TKs5-Nck1 complex; TKs5-Nck1 complex; oncolytic avian reovirus; p53-PTEN-FAK-Src; invadopodia formation; p17

Avian reovirus (ARV) is an oncolytic virus that induces autophagy and apoptosis in cancer cells, modulates the immune response, and exposes tumor-associated antigens to the immune system, making it a promising candidate for cancer therapy. Cancer cell migration and invadopodia formation are essentia...