Osteonecrosis of the Femoral Head: Lipotoxicity Exacerbation in MSC and Modifications of the Bone Marrow Fluid

• Published in: Endocrinology (Philadelphia) Vol. 158; no. 3; pp. 490 - 502
• Main Authors: Gillet, Celine, Dalla Valle, Antoine, Gaspard, Nathalie, Spruyt, Delphine, Vertongen, Pascale, Lechanteur, Jessica, Rigutto, Sabrina, Dragan, Elena-Raluca, Heuschling, Audrey, Gangji, Valerie, Rasschaert, Joanne
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2017
• Subjects: Adipocytes; Adipogenesis; Adipogenesis - drug effects; Adult; Apoptosis; Biomedical materials; Bone diseases; Bone marrow; Bone Marrow - metabolism; Bone remodeling; Carnitine; Case-Control Studies; Coenzyme A; Cytokines; Desaturase; Endocrinology; Enlargement; Extracellular signal-regulated kinase; Fatty acids; Female; Femur; Femur Head Necrosis - blood; Hip; Humans; Interleukin 8; Interleukins; Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stromal Cells - drug effects; Mesenchyme; Oleic Acid - blood; Oleic Acid - toxicity; Osteoblastogenesis; Osteoblasts; Osteonecrosis; Palmitic acid; Palmitic Acid - blood; Palmitic Acid - toxicity; Pathogenesis; Phenotypes; Stromal cells; Surgical implants; Toxicity

Osteonecrosis of the femoral head (ON) is a multifactorial bone disease that can evolve to a progressive destruction of the hip joint. Different pathogenic processes have been proposed, among them, an increase of bone marrow (BM) fat resulting from adipocyte accumulation. Marrow adipocytes are activ...