Emergence, persistence, and positive selection of yellow fever virus in Colombia

• Published in: Frontiers in microbiology Vol. 16; p. 1548556
• Main Authors: Perez, Lester J., Perez-Restrepo, Laura S., Ciuoderis, Karl, Usuga, Jaime, Moreno, Isabel, Vargas, Vanessa, Arévalo-Arbelaez, Angela J., Berg, Michael G., Cloherty, Gavin A., Hernández-Ortiz, Juan Pablo, Osorio, Jorge E.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.04.2025
• Subjects: acute febrile illness; deimmunization; Microbiology; phylodynamic; positive selection; whole genome sequencing; yellow fever virus; whole genome sequencing; deimmunization; positive selection; yellow fever virus; acute febrile illness; phylodynamic

Yellow fever virus (YFV) is an arbovirus that causes acute febrile illness (AFI), in tropical areas of South America and Africa. Through a 2020–2023 AFI study in Leticia, Colombia, leveraging metagenomic next-generation sequencing (mNGS), we identified and isolated YFV (LET1450). Phylogenetic analys...