Determination of captopril in human plasma, using solid phase extraction and high-performance liquid chromatography, coupled to mass spectrometry: Application to bioequivalence study - Rezende, Kênnia R.; Mundim, Iram M.; Teixeira, Leonardo S.; Souza, Weidson C.; Ramos, Douglas R.; Cardoso, Cláudio R.F.; Souza, Inácia C.; Gratão, Mário Z.; Bellório, Karini B. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007)
Keywords: Analysis; Analytical, structural and metabolic biochemistry; Angiotensin-Converting Enzyme Inhibitors - blood; Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics; Bioequivalence; Biological and medical sciences; Calibration; Captopril; Captopril - blood; Captopril - pharmacokinetics; Chromatography, High Pressure Liquid - methods; Fundamental and applied biological sciences. Psychology; General pharmacology; Humans; LC-MS; Medical sciences; Pharmacokinetics; Pharmacology. Drug treatments; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; SPE; Spectrometry, Mass, Electrospray Ionization - methods; Stability validation; Tandem Mass Spectrometry - methods; Therapeutic Equivalency; SPE; Stability validation; Bioequivalence; Pharmacokinetics; Captopril; LC–MS; Solid phase extraction; Biological fluid; HPLC chromatography; Determination; Blood plasma; Peptidyl-dipeptidase A; Captopril; LC-MS; SPE; Bioequivalence; Pharmacokinetics; Stability validation; Quantitative analysis; Human; Validation; Stability; Enzyme; Coupled method; Enzyme inhibitor; Liquid chromatography; Peptidases; Hydrolases; Peptidyl-dipeptidases; Antihypertensive agent; Mass spectrometry; ACE inhibitor; Physicochemical properties