Epidemiology, Pathophysiology, Stratification, and Natural History of Pulmonary Embolism
Pulmonary embolism (PE) is a common and potentially fatal form of venous thromboembolism that can be challenging to diagnose and manage. PE occurs when there is obstruction of the pulmonary vasculature and is a common cause of morbidity and mortality in the United States. A combination of acquired a...
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Published in | Techniques in vascular and interventional radiology Vol. 20; no. 3; pp. 135 - 140 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.09.2017
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Abstract | Pulmonary embolism (PE) is a common and potentially fatal form of venous thromboembolism that can be challenging to diagnose and manage. PE occurs when there is obstruction of the pulmonary vasculature and is a common cause of morbidity and mortality in the United States. A combination of acquired and inherited factors may contribute to the development of this disease and should be considered, since they have implications for both susceptibility to PE and treatment. Patients with suspected PE should be evaluated efficiently to diagnose and administer therapy as soon as possible, but the presentation of PE is variable and nonspecific so diagnosis is challenging. PE can range from small, asymptomatic blood clots to large emboli that can occlude the pulmonary arteries causing sudden cardiovascular collapse and death. Thus, risk stratification is critical to both the prognosis and management of acute PE. In this review, we discuss the epidemiology, risk factors, pathophysiology, and natural history of PE and deep vein thrombosis. |
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AbstractList | Pulmonary embolism (PE) is a common and potentially fatal form of venous thromboembolism that can be challenging to diagnose and manage. PE occurs when there is obstruction of the pulmonary vasculature and is a common cause of morbidity and mortality in the United States. A combination of acquired and inherited factors may contribute to the development of this disease and should be considered, since they have implications for both susceptibility to PE and treatment. Patients with suspected PE should be evaluated efficiently to diagnose and administer therapy as soon as possible, but the presentation of PE is variable and nonspecific so diagnosis is challenging. PE can range from small, asymptomatic blood clots to large emboli that can occlude the pulmonary arteries causing sudden cardiovascular collapse and death. Thus, risk stratification is critical to both the prognosis and management of acute PE. In this review, we discuss the epidemiology, risk factors, pathophysiology, and natural history of PE and deep vein thrombosis. |
Author | Hagan, Kaitlin A. Kabrhel, Christopher Young, Michael N. Giordano, Nicholas J. Jansson, Paul S. |
Author_xml | – sequence: 1 givenname: Nicholas J. surname: Giordano fullname: Giordano, Nicholas J. email: ngiordano@mgh.harvard.edu organization: Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital, Boston, MA – sequence: 2 givenname: Paul S. surname: Jansson fullname: Jansson, Paul S. organization: Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, MA – sequence: 3 givenname: Michael N. surname: Young fullname: Young, Michael N. organization: Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA – sequence: 4 givenname: Kaitlin A. surname: Hagan fullname: Hagan, Kaitlin A. organization: Channing Division of Network Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA – sequence: 5 givenname: Christopher surname: Kabrhel fullname: Kabrhel, Christopher organization: Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital, Boston, MA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29029707$$D View this record in MEDLINE/PubMed |
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Snippet | Pulmonary embolism (PE) is a common and potentially fatal form of venous thromboembolism that can be challenging to diagnose and manage. PE occurs when there... |
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SubjectTerms | Disease Progression DVT Humans Natural History Predictive Value of Tests Prognosis Pulmonary Embolism - classification Pulmonary Embolism - diagnosis Pulmonary Embolism - epidemiology Pulmonary Embolism - physiopathology Risk Assessment Risk Factors Venous Thromboembolism - classification Venous Thromboembolism - diagnosis Venous Thromboembolism - epidemiology Venous Thromboembolism - physiopathology Venous Thrombosis - classification Venous Thrombosis - diagnosis Venous Thrombosis - epidemiology Venous Thrombosis - physiopathology VTE |
Title | Epidemiology, Pathophysiology, Stratification, and Natural History of Pulmonary Embolism |
URI | https://dx.doi.org/10.1053/j.tvir.2017.07.002 https://www.ncbi.nlm.nih.gov/pubmed/29029707 https://search.proquest.com/docview/1951415716 |
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