Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system

• Published in: Journal of controlled release Vol. 100; no. 1; pp. 87 - 95
• Main Authors: Leitner, Verena M., Guggi, Davide, Krauland, Alexander H., Bernkop-Schnürch, Andreas
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 05.11.2004; Elsevier
• Subjects: Acrylic Resins - administration & dosage; Administration, Intranasal; Animals; Biological and medical sciences; Cysteine - administration & dosage; Drug Delivery Systems; General pharmacology; Glutathione; Glutathione - administration & dosage; hGH; Human Growth Hormone - administration & dosage; Human Growth Hormone - chemistry; Human Growth Hormone - pharmacokinetics; Male; Medical sciences; Microparticulate delivery system; Noninvasive peptide delivery; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Rats; Rats, Wistar; Thiolated polymers; PBS; MWCO; Microparticulate delivery system; Thiolated polymers; hGH; PCP-Cys; PCP; GSH; Noninvasive peptide delivery; Glutathione; Human; Delivery system; Evaluation; Pharmaceutical technology; Peptides; Control release polymer; Somatotropin hormone; Intranasal administration; In vitro; In vivo; Somatropin; Neurohypophyseal hormone; Non invasive method; Microparticle

It was the aim of this study to develop and evaluate a nasal microparticulate delivery system for human growth hormone (hGH) based on the thiomer polycarbophil-cysteine (PCP-Cys) in combination with the permeation mediator glutathione (GSH). Microparticles were prepared by dissolving PCP-Cys/GSH/hGH...