Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study

• Published in: Psychopharmacologia Vol. 191; no. 2; pp. 333 - 339
• Main Authors: Klein, Nikolas, Sacher, Julia, Geiss-Granadia, Thomas, Mossaheb, Nilufar, Attarbaschi, Trawat, Lanzenberger, Rupert, Spindelegger, Christoph, Holik, Alexander, Asenbaum, Susanne, Dudczak, Robert, Tauscher, Johannes, Kasper, Siegfried
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.04.2007; Springer Nature B.V
• Subjects: Adult; Area Under Curve; Biological and medical sciences; Blood tests; Brain; Cerebellum; Cinanserin - analogs & derivatives; Citalopram - pharmacokinetics; Citalopram - pharmacology; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Inhibitor drugs; Male; Medical sciences; Mesencephalon - drug effects; Mesencephalon - metabolism; Neurology; Neuropharmacology; Neurotransmitters; Pharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Radiopharmaceuticals; Serotonin Plasma Membrane Transport Proteins - drug effects; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - pharmacology; Stereoisomerism; Time Factors; Tissue Distribution; Tomography; Tomography, Emission-Computed, Single-Photon; [123I]ADAM; Serotonin; Escitalopram; Psychotropic; Reuptake inhibitor; Photon; SPECT; Selective serotonin reuptake inhibitor; Citalopram; Multiple dose; 5-HTT; SERT; Serotonin transporter; Occupancy; Neurotransmitter; Antidepressant agent; Emission tomography

Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using th...