Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study - Klein, Nikolas; Sacher, Julia; Geiss-Granadia, Thomas; Mossaheb, Nilufar; Attarbaschi, Trawat; Lanzenberger, Rupert; Spindelegger, Christoph; Holik, Alexander; Asenbaum, Susanne; Dudczak, Robert; Tauscher, Johannes; Kasper, Siegfried (Psychopharmacologia, 2007)
Keywords: Adult; Area Under Curve; Biological and medical sciences; Blood tests; Brain; Cerebellum; Cinanserin - analogs & derivatives; Citalopram - pharmacokinetics; Citalopram - pharmacology; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Inhibitor drugs; Male; Medical sciences; Mesencephalon - drug effects; Mesencephalon - metabolism; Neurology; Neuropharmacology; Neurotransmitters; Pharmacology; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Radiopharmaceuticals; Serotonin Plasma Membrane Transport Proteins - drug effects; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin Uptake Inhibitors - pharmacokinetics; Serotonin Uptake Inhibitors - pharmacology; Stereoisomerism; Time Factors; Tissue Distribution; Tomography; Tomography, Emission-Computed, Single-Photon; [123I]ADAM; Serotonin; Escitalopram; Psychotropic; Reuptake inhibitor; Photon; SPECT; Selective serotonin reuptake inhibitor; Citalopram; Multiple dose; 5-HTT; SERT; Serotonin transporter; Occupancy; Neurotransmitter; Antidepressant agent; Emission tomography