Drug–target interaction prediction: databases, web servers and computational models

• Published in: Briefings in bioinformatics Vol. 17; no. 4; pp. 696 - 712
• Main Authors: Chen, Xing, Yan, Chenggang Clarence, Zhang, Xiaotian, Zhang, Xu, Dai, Feng, Yin, Jian, Zhang, Yongdong
• Format: Journal Article
• Language: English
• Published: England 01.07.2016
• Subjects: bioactive properties; bioassays; Databases, Factual; Drug Delivery Systems; Drug Discovery; drugs; Humans; Internet; neoplasms; precision medicine; prediction; screening; sequence analysis; computational models; drug–target interactions prediction; drug discovery; machine learning; biological networks

Identification of drug-target interactions is an important process in drug discovery. Although high-throughput screening and other biological assays are becoming available, experimental methods for drug-target interaction identification remain to be extremely costly, time-consuming and challenging e...