Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions
Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse...
Saved in:
| Published in | Diabetes (New York, N.Y.) Vol. 63; no. 7; pp. 2332 - 2343 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria, VA
American Diabetes Association
01.07.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0012-1797 1939-327X 1939-327X |
| DOI | 10.2337/db13-1563 |
Cover
| Abstract | Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIPgfp/+]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIPgfp/gfp]), GIP secretion was undetectable. When fed standard chow, GIPgfp/+ and GIPgfp/gfp mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIPgfp/gfp mice and preserved in GIPgfp/+ mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIPgfp/+, and GIPgfp/gfp mice, while insulin secretion remained lower. GIPgfp/+ and GIPgfp/gfp mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value. |
|---|---|
| AbstractList | Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIP...]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIP...]), GIP secretion was undetectable. When fed standard chow, GIP... and GIP... mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIPgfp/gfp mice and preserved in GIP... mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIP..., and GIP... mice, while insulin secretion remained lower. GIP... and GIP... mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value. (ProQuest: ... denotes formulae/symbols omitted.) Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIPgfp/+]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIPgfp/gfp]), GIP secretion was undetectable. When fed standard chow, GIPgfp/+ and GIPgfp/gfp mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIPgfp/gfp mice and preserved in GIPgfp/+ mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIPgfp/+, and GIPgfp/gfp mice, while insulin secretion remained lower. GIPgfp/+ and GIPgfp/gfp mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value. Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIP(gfp/+)]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIP(gfp/gfp)]), GIP secretion was undetectable. When fed standard chow, GIP(gfp/+) and GIP(gfp/gfp) mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIP(gfp/gfp) mice and preserved in GIP(gfp/+) mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIP(gfp/+), and GIP(gfp/gfp) mice, while insulin secretion remained lower. GIP(gfp/+) and GIP(gfp/gfp) mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value.Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIP(gfp/+)]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIP(gfp/gfp)]), GIP secretion was undetectable. When fed standard chow, GIP(gfp/+) and GIP(gfp/gfp) mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIP(gfp/gfp) mice and preserved in GIP(gfp/+) mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIP(gfp/+), and GIP(gfp/gfp) mice, while insulin secretion remained lower. GIP(gfp/+) and GIP(gfp/gfp) mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value. Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored the impact of reduced GIP levels in vivo on glucose homeostasis, bone formation, and fat accumulation in a novel GIP-GFP knock-in (KI) mouse. We generated GIP-GFP KI mice with a truncated prepro-GIP gene. The phenotype was assessed in heterozygous and homozygous states in mice on a control fat diet and a high-fat diet (HFD) in vivo and in vitro. Heterozygous GIP-GFP KI mice (GIP-reduced mice [GIP(gfp/+)]) exhibited reduced GIP secretion; in the homozygous state (GIP-lacking mice [GIP(gfp/gfp)]), GIP secretion was undetectable. When fed standard chow, GIP(gfp/+) and GIP(gfp/gfp) mice showed mild glucose intolerance with decreased insulin levels; bone volume was decreased in GIP(gfp/gfp) mice and preserved in GIP(gfp/+) mice. Under an HFD, glucose levels during an oral glucose tolerance test were similar in wild-type, GIP(gfp/+), and GIP(gfp/gfp) mice, while insulin secretion remained lower. GIP(gfp/+) and GIP(gfp/gfp) mice showed reduced obesity and reduced insulin resistance, accompanied by higher fat oxidation and energy expenditure. GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value. |
| Author | Nasteska, Daniela Harada, Norio Shibue, Kimitaka Suzuki, Kazuyo Joo, Erina Iwasaki, Kanako Harada, Takanari Inagaki, Nobuya Yamane, Shunsuke Hamasaki, Akihiro |
| Author_xml | – sequence: 1 givenname: Daniela surname: Nasteska fullname: Nasteska, Daniela organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 2 givenname: Norio surname: Harada fullname: Harada, Norio organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 3 givenname: Kazuyo surname: Suzuki fullname: Suzuki, Kazuyo organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 4 givenname: Shunsuke surname: Yamane fullname: Yamane, Shunsuke organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 5 givenname: Akihiro surname: Hamasaki fullname: Hamasaki, Akihiro organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 6 givenname: Erina surname: Joo fullname: Joo, Erina organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 7 givenname: Kanako surname: Iwasaki fullname: Iwasaki, Kanako organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 8 givenname: Kimitaka surname: Shibue fullname: Shibue, Kimitaka organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 9 givenname: Takanari surname: Harada fullname: Harada, Takanari organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 10 givenname: Nobuya surname: Inagaki fullname: Inagaki, Nobuya organization: Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28603377$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24584548$$D View this record in MEDLINE/PubMed |
| BookMark | eNplkV9rFTEQxYNU7G31wS8gARHsw9r822T3sVxte6FQUQu-hWwya1P3Jm2SFfrtzba3CJV5GBh-5zCcc4D2QgyA0FtKPjHO1bEbKG9oK_kLtKI97xvO1M89tCKEsoaqXu2jg5xvCCGyziu0z0TbiVZ0K_R7fZ1i8BZ_Azfb4mPAccRnm6_4O9gED4eTaYI_3hTI-HKA7Ms9NsHhTcjz5ENVZp-LCRbwVXCQ8Ln_dd2cmoI_eyh4HYPzi09-jV6OZsrwZrcP0dXplx_r8-bi8myzPrlorGCsNJI41TE5GsGBcUr7kTnbgrDEcDeMoretam0nRSesAKtAEtsNowVHu74F4Ifo46PvbYp3M-Sitz5bmCYTIM5Z01YQRYnkvKLvn6E3cU6hfqep5EoKxhmr1LsdNQ9bcPo2-a1J9_opxgp82AEmWzONqabh8z-uk6T2pCp3_MjZFHNOMGrri1nCKcn4SVOil0L1UqheCq2Ko2eKJ9P_2b83up68 |
| CODEN | DIAEAZ |
| CitedBy_id | crossref_primary_10_1016_j_molmet_2020_101139 crossref_primary_10_1186_s40348_023_00170_6 crossref_primary_10_1016_j_ejpb_2022_10_019 crossref_primary_10_1038_s41467_017_02488_y crossref_primary_10_1152_ajpendo_00352_2017 crossref_primary_10_3390_nu13041242 crossref_primary_10_1172_jci_insight_91981 crossref_primary_10_1016_j_molmet_2020_101090 crossref_primary_10_3389_fendo_2022_891586 crossref_primary_10_1111_jdi_12495 crossref_primary_10_1210_endrev_bnz002 crossref_primary_10_1194_jlr_M075028 crossref_primary_10_1016_j_cgh_2016_08_002 crossref_primary_10_1016_j_bbacli_2015_05_001 crossref_primary_10_2337_dbi21_0001 crossref_primary_10_1152_physiolgenomics_00021_2018 crossref_primary_10_1007_s00125_015_3691_8 crossref_primary_10_1016_j_bcp_2017_02_012 crossref_primary_10_1038_s41467_021_27934_w crossref_primary_10_3390_biology13050335 crossref_primary_10_1007_s00125_015_3653_1 crossref_primary_10_1080_10408398_2021_1895057 crossref_primary_10_1016_j_peptides_2017_11_021 crossref_primary_10_3389_fendo_2018_00754 crossref_primary_10_1210_en_2018_00336 crossref_primary_10_1016_j_ejcb_2023_151320 crossref_primary_10_1111_jdi_13059 crossref_primary_10_3390_nu11081878 crossref_primary_10_1172_JCI126107 crossref_primary_10_1016_j_molmet_2024_102074 crossref_primary_10_1042_CS20190579 crossref_primary_10_1371_journal_pone_0249239 crossref_primary_10_1038_s41467_020_18751_8 crossref_primary_10_1016_j_phymed_2019_152946 crossref_primary_10_1177_1179551419875453 crossref_primary_10_1016_j_molmet_2019_08_006 crossref_primary_10_1210_endocr_bqz029 crossref_primary_10_1172_JCI182325 crossref_primary_10_1002_path_4655 crossref_primary_10_2337_db16_0758 crossref_primary_10_1016_j_cmet_2017_11_003 crossref_primary_10_1161_ATVBAHA_115_306108 crossref_primary_10_1007_s00125_015_3862_7 crossref_primary_10_1186_s13073_023_01263_7 crossref_primary_10_1002_jbmr_4004 crossref_primary_10_1016_j_jdiacomp_2019_107415 crossref_primary_10_1016_j_isci_2021_102963 crossref_primary_10_1152_ajpendo_00016_2022 crossref_primary_10_1152_ajpendo_00080_2017 crossref_primary_10_1016_j_ejps_2016_05_006 crossref_primary_10_1530_EJE_16_0958 crossref_primary_10_1016_j_jacl_2016_09_006 crossref_primary_10_1016_j_jnutbio_2016_12_016 crossref_primary_10_1111_jdi_12390 crossref_primary_10_1016_j_acuro_2014_05_014 crossref_primary_10_1016_j_peptides_2017_12_008 crossref_primary_10_1016_j_ejphar_2021_174635 crossref_primary_10_1096_fj_201700518R crossref_primary_10_1007_s11255_014_0823_x crossref_primary_10_2169_naika_112_1613 crossref_primary_10_1016_j_tem_2024_07_022 crossref_primary_10_1038_s41598_022_22511_7 crossref_primary_10_1111_jdi_12779 crossref_primary_10_1152_ajpendo_00646_2020 crossref_primary_10_1210_en_2017_00090 crossref_primary_10_3389_fendo_2022_921125 crossref_primary_10_1111_jdi_12942 crossref_primary_10_1126_scitranslmed_aat3392 crossref_primary_10_1152_ajpgi_00054_2018 crossref_primary_10_3389_fendo_2022_821028 crossref_primary_10_3390_nu10080979 crossref_primary_10_1080_17446651_2020_1740588 crossref_primary_10_3389_fcell_2021_703966 crossref_primary_10_1093_ejendo_lvac004 crossref_primary_10_3389_fendo_2018_00324 crossref_primary_10_1007_s13340_017_0317_z crossref_primary_10_1152_ajpendo_00543_2014 crossref_primary_10_1016_j_lfs_2021_119038 crossref_primary_10_1016_j_peptides_2019_170208 crossref_primary_10_1177_1179551419888871 crossref_primary_10_2147_DMSO_S351982 crossref_primary_10_3390_ijms21041509 crossref_primary_10_1016_j_peptides_2019_170203 crossref_primary_10_1089_jmf_2017_3995 crossref_primary_10_4327_jsnfs_76_133 crossref_primary_10_1016_j_molmet_2017_01_006 crossref_primary_10_1111_bph_13323 crossref_primary_10_1016_j_mce_2014_10_025 crossref_primary_10_1016_j_cmet_2014_10_016 crossref_primary_10_1016_j_molmet_2019_11_018 crossref_primary_10_3748_wjg_v24_i4_461 crossref_primary_10_1016_j_peptides_2024_171168 crossref_primary_10_3390_nu11071477 crossref_primary_10_3390_nu13020351 crossref_primary_10_1016_j_peptides_2016_10_011 crossref_primary_10_1016_j_peptides_2019_170202 crossref_primary_10_1111_jdi_12289 crossref_primary_10_29219_fnr_v66_7870 crossref_primary_10_1016_j_orcp_2017_05_003 crossref_primary_10_1210_endocr_bqaa102 crossref_primary_10_1016_j_peptides_2024_171212 crossref_primary_10_1111_dom_14736 crossref_primary_10_3390_ijms26031142 crossref_primary_10_1016_j_acuroe_2015_02_005 crossref_primary_10_3389_fendo_2019_00075 crossref_primary_10_3389_fphar_2024_1372399 crossref_primary_10_1080_16546628_2017_1361778 crossref_primary_10_3390_foods10081691 crossref_primary_10_3390_nu11051045 crossref_primary_10_1016_j_peptides_2019_170233 crossref_primary_10_1172_JCI130755 crossref_primary_10_1016_j_molmet_2024_102006 crossref_primary_10_1016_j_jcjd_2018_01_006 crossref_primary_10_1016_j_peptides_2019_170230 crossref_primary_10_1152_ajpendo_00345_2015 crossref_primary_10_1515_hsz_2020_0195 crossref_primary_10_1016_j_molmed_2016_03_005 crossref_primary_10_1096_fj_201801783RR crossref_primary_10_1152_ajpendo_00200_2018 crossref_primary_10_1016_j_cmet_2023_07_010 crossref_primary_10_1186_s12937_017_0233_x crossref_primary_10_1016_j_cmet_2020_02_014 crossref_primary_10_1021_acs_jafc_6b03424 crossref_primary_10_1080_09637486_2019_1711362 crossref_primary_10_1111_jdi_12978 crossref_primary_10_3389_fphys_2018_01358 crossref_primary_10_2169_naika_108_1713 crossref_primary_10_1111_jdi_12467 crossref_primary_10_1038_s42255_023_00966_w crossref_primary_10_1152_ajpendo_00329_2022 crossref_primary_10_2337_db21_1166 crossref_primary_10_1002_osp4_164 crossref_primary_10_1007_s00125_016_3935_2 crossref_primary_10_1016_j_peptides_2019_170183 |
| Cites_doi | 10.1152/ajpendo.00358.2007 10.1007/BF00429703 10.1111/j.2040-1124.2010.00078.x 10.1210/en.2011-2170 10.1172/JCI25483 10.1016/S0016-5085(72)80144-6 10.1042/bj1880193 10.1073/pnas.96.26.14843 10.1210/endo.133.1.8319572 10.1210/endo-128-6-3175 10.1152/ajpendo.00364.2006 10.1111/jdi.12065 10.1093/jn/125.2.183 10.1016/j.bbrc.2007.09.128 10.1016/j.bbrc.2008.08.052 10.2337/db06-S011 10.2337/db07-1124 10.1111/j.1464-5491.2008.02455.x 10.1038/nm727 10.1007/s00125-008-1202-x 10.1210/me.2005-0187 10.1210/jcem-37-5-826 10.1371/journal.pone.0022814 10.1371/journal.pone.0009590 10.1152/ajpendo.00460.2007 10.1016/j.bbrc.2005.07.164 10.1053/j.gastro.2007.09.005 10.1016/j.cmet.2012.10.019 10.1152/jn.00866.2010 10.1053/j.gastro.2007.03.054 10.2337/db09-0519 10.1172/JCI200420518 10.1111/j.2040-1124.2011.00143.x 10.1074/jbc.M500540200 10.1074/jbc.M112.423137 10.1074/jbc.M710466200 10.1152/ajpendo.90440.2008 10.1016/S0165-6147(03)00031-2 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS 2014 by the American Diabetes Association. Copyright American Diabetes Association Jul 2014 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: 2014 by the American Diabetes Association. – notice: Copyright American Diabetes Association Jul 2014 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM K9. NAPCQ 7X8 |
| DOI | 10.2337/db13-1563 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1939-327X |
| EndPage | 2343 |
| ExternalDocumentID | 3530592281 24584548 28603377 10_2337_db13_1563 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
| GroupedDBID | --- .55 .XZ 08P 0R~ 18M 29F 2WC 354 4.4 53G 5GY 5RE 5RS 5VS 6PF 8GL 8R4 8R5 AAFWJ AAKAS AAQQT AAWTL AAYEP AAYXX ABOCM ACGFO ACGOD ACPRK ADBBV ADGHP ADZCM AEGXH AENEX AERZD AHMBA AIAGR AIZAD ALIPV ALMA_UNASSIGNED_HOLDINGS BAWUL BES BTFSW CITATION CS3 DIK DU5 E3Z EBS EDB EJD EMOBN EX3 F5P FRP GX1 H13 HZ~ IAG IAO IEA IHR INH INR IOF IPO K2M KQ8 L7B M5~ O5R O5S O9- OB3 OHH OK1 OVD P2P PCD Q2X RHI RPM SJN SV3 TDI TEORI TR2 VVN W8F WH7 WOQ WOW X7M YFH YHG YOC ZY1 ~KM .GJ 1CY 7RV 7X7 88E 88I 8AF 8AO 8C1 8F7 8FE 8FH 8FI 8FJ 8G5 AAYJJ AAYOK ABUWG AFFNX AFKRA AI. AZQEC BBNVY BCR BCU BEC BENPR BHPHI BKEYQ BKNYI BLC BPHCQ BVXVI C1A CCPQU DWQXO FYUFA GICCO GNUQQ GUQSH HCIFZ HMCUK H~9 IQODW ITC J5H K-O K9- LK8 M0R M1P M2O M2P M2Q M7P MVM N4W NAPCQ PEA PHGZT PQQKQ PROAC PSQYO S0X SJFOW UKHRP VH1 XOL YQJ ZGI ZXP 3V. AFHIN CGR CUY CVF ECM EIF NPM PKN RHF K9. 7X8 |
| ID | FETCH-LOGICAL-c422t-60d7826fa43e23119f2dc5e4c0a3dbf49c575c86484c4ec7e60c8bfced1895ee3 |
| ISSN | 0012-1797 1939-327X |
| IngestDate | Thu Sep 04 19:42:14 EDT 2025 Fri Jul 25 19:28:48 EDT 2025 Wed Feb 19 02:43:37 EST 2025 Wed Apr 02 07:24:01 EDT 2025 Tue Aug 05 12:00:18 EDT 2025 Thu Apr 24 22:58:41 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | Endocrinopathy Obesity Secretion Diabetes mellitus Nutrition disorder Metabolic diseases Feeding Target tissue resistance Chronic Gastrointestinal hormone Diet Insulin resistance Gastric inhibitory peptide Nutritional status |
| Language | English |
| License | CC BY 4.0 2014 by the American Diabetes Association. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c422t-60d7826fa43e23119f2dc5e4c0a3dbf49c575c86484c4ec7e60c8bfced1895ee3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://hdl.handle.net/2433/189090 |
| PMID | 24584548 |
| PQID | 1637642322 |
| PQPubID | 34443 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_1540710633 proquest_journals_1637642322 pubmed_primary_24584548 pascalfrancis_primary_28603377 crossref_citationtrail_10_2337_db13_1563 crossref_primary_10_2337_db13_1563 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-07-01 |
| PublicationDateYYYYMMDD | 2014-07-01 |
| PublicationDate_xml | – month: 07 year: 2014 text: 2014-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Alexandria, VA |
| PublicationPlace_xml | – name: Alexandria, VA – name: United States – name: New York |
| PublicationTitle | Diabetes (New York, N.Y.) |
| PublicationTitleAlternate | Diabetes |
| PublicationYear | 2014 |
| Publisher | American Diabetes Association |
| Publisher_xml | – name: American Diabetes Association |
| References | Baggio (2022031223273187900_B3) 2007; 132 Parker (2022031223273187900_B21) 2009; 52 Althage (2022031223273187900_B19) 2008; 283 Kieffer (2022031223273187900_B27) 2003; 24 Yamada (2022031223273187900_B6) 2006; 55 Suzuki (2022031223273187900_B15) 2013; 288 Seino (2022031223273187900_B32) 2013; 4 Yamada (2022031223273187900_B40) 2007; 364 Harada (2022031223273187900_B31) 2011; 2 Zhong (2022031223273187900_B26) 2007; 292 Creutzfeldt (2022031223273187900_B28) 1978; 14 Naitoh (2022031223273187900_B37) 2008; 376 Miyawaki (2022031223273187900_B12) 2002; 8 Tsukiyama (2022031223273187900_B13) 2006; 20 Pacheco-Pantoja (2022031223273187900_B25) 2011 Knapper (2022031223273187900_B33) 1995; 125 Mehran (2022031223273187900_B36) 2012; 16 Preitner (2022031223273187900_B16) 2004; 113 Roberge (2022031223273187900_B24) 1993; 133 Renner (2022031223273187900_B9) 2010; 59 Song (2022031223273187900_B34) 2007; 133 Flatt (2022031223273187900_B2) 2008; 25 Pederson (2022031223273187900_B4) 1972; 62 Kim (2022031223273187900_B10) 2005; 280 Parkin (2022031223273187900_B35) 1980; 188 Fujita (2022031223273187900_B20) 2008; 295 Hansotia (2022031223273187900_B29) 2007; 117 Zhou (2022031223273187900_B38) 2005; 335 Krarup (2022031223273187900_B1) 1985; 249 McClean (2022031223273187900_B14) 2007; 293 Habib (2022031223273187900_B22) 2012; 153 Faivre (2022031223273187900_B39) 2011; 105 Widenmaier (2022031223273187900_B11) 2010; 5 Miyawaki (2022031223273187900_B7) 1999; 96 Vollmer (2022031223273187900_B18) 2008; 57 Harada (2022031223273187900_B30) 2008; 294 Dupre (2022031223273187900_B5) 1973; 37 Yamane (2022031223273187900_B17) 2012; 3 Herbach (2022031223273187900_B8) 2011; 6 Brubaker (2022031223273187900_B23) 1991; 128 |
| References_xml | – volume: 294 start-page: E61 year: 2008 ident: 2022031223273187900_B30 article-title: A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00358.2007 – volume: 14 start-page: 15 year: 1978 ident: 2022031223273187900_B28 article-title: Gastric inhibitory polypeptide (GIP) and insulin in obesity: increased response to stimulation and defective feedback control of serum levels publication-title: Diabetologia doi: 10.1007/BF00429703 – volume: 2 start-page: 193 year: 2011 ident: 2022031223273187900_B31 article-title: Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects publication-title: J Diabetes Invest doi: 10.1111/j.2040-1124.2010.00078.x – volume: 153 start-page: 3054 year: 2012 ident: 2022031223273187900_B22 article-title: Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry publication-title: Endocrinology doi: 10.1210/en.2011-2170 – volume: 117 start-page: 143 year: 2007 ident: 2022031223273187900_B29 article-title: Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure publication-title: J Clin Invest doi: 10.1172/JCI25483 – volume: 62 start-page: 393 year: 1972 ident: 2022031223273187900_B4 article-title: Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure “gastric inhibitory polypeptide” publication-title: Gastroenterology doi: 10.1016/S0016-5085(72)80144-6 – volume: 188 start-page: 193 year: 1980 ident: 2022031223273187900_B35 article-title: Effects of glucose and insulin on the activation of lipoprotin lipase and on protein-synthesis in rat adipose tissue publication-title: Biochem J doi: 10.1042/bj1880193 – volume: 96 start-page: 14843 year: 1999 ident: 2022031223273187900_B7 article-title: Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.96.26.14843 – volume: 133 start-page: 233 year: 1993 ident: 2022031223273187900_B24 article-title: Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop publication-title: Endocrinology doi: 10.1210/endo.133.1.8319572 – volume: 128 start-page: 3175 year: 1991 ident: 2022031223273187900_B23 article-title: Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides publication-title: Endocrinology doi: 10.1210/endo-128-6-3175 – volume: 292 start-page: E543 year: 2007 ident: 2022031223273187900_B26 article-title: Effects of glucose-dependent insulinotropic peptide on osteoclast function publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00364.2006 – volume: 4 start-page: 108 year: 2013 ident: 2022031223273187900_B32 article-title: Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas publication-title: J Diabetes Invest doi: 10.1111/jdi.12065 – volume: 125 start-page: 183 year: 1995 ident: 2022031223273187900_B33 article-title: Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue publication-title: J Nutr doi: 10.1093/jn/125.2.183 – start-page: 12 volume-title: BMC Physiol year: 2011 ident: 2022031223273187900_B25 article-title: Receptors and effects of gut hormones in three osteoblastic cell lines – volume: 364 start-page: 175 year: 2007 ident: 2022031223273187900_B40 article-title: Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.09.128 – volume: 376 start-page: 21 year: 2008 ident: 2022031223273187900_B37 article-title: Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2008.08.052 – volume: 249 start-page: E195 year: 1985 ident: 2022031223273187900_B1 article-title: Responses and molecular heterogeneity of IR-GIP after intraduodenal glucose and fat publication-title: Am J Physiol – volume: 55 start-page: S86 year: 2006 ident: 2022031223273187900_B6 article-title: Pancreatic and extrapancreatic effects of gastric inhibitory polypeptide publication-title: Diabetes doi: 10.2337/db06-S011 – volume: 57 start-page: 678 year: 2008 ident: 2022031223273187900_B18 article-title: Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance publication-title: Diabetes doi: 10.2337/db07-1124 – volume: 25 start-page: 759 year: 2008 ident: 2022031223273187900_B2 article-title: Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes? publication-title: Diabet Med doi: 10.1111/j.1464-5491.2008.02455.x – volume: 8 start-page: 738 year: 2002 ident: 2022031223273187900_B12 article-title: Inhibition of gastric inhibitory polypeptide signaling prevents obesity publication-title: Nat Med doi: 10.1038/nm727 – volume: 52 start-page: 289 year: 2009 ident: 2022031223273187900_B21 article-title: Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells publication-title: Diabetologia doi: 10.1007/s00125-008-1202-x – volume: 20 start-page: 1644 year: 2006 ident: 2022031223273187900_B13 article-title: Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion publication-title: Mol Endocrinol doi: 10.1210/me.2005-0187 – volume: 37 start-page: 826 year: 1973 ident: 2022031223273187900_B5 article-title: Stimulation of insulin secretion by gastric inhibitory polypeptide in man publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-37-5-826 – volume: 6 start-page: e22814 year: 2011 ident: 2022031223273187900_B8 article-title: Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice publication-title: PLoS One doi: 10.1371/journal.pone.0022814 – volume: 5 start-page: e9590 year: 2010 ident: 2022031223273187900_B11 article-title: A GIP receptor agonist exhibits β-cell anti-apoptotic actions in rat models of diabetes resulting in improved β-cell function and glycemic control publication-title: PLoS One doi: 10.1371/journal.pone.0009590 – volume: 293 start-page: E1746 year: 2007 ident: 2022031223273187900_B14 article-title: GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00460.2007 – volume: 335 start-page: 937 year: 2005 ident: 2022031223273187900_B38 article-title: Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.07.164 – volume: 133 start-page: 1796 year: 2007 ident: 2022031223273187900_B34 article-title: Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.09.005 – volume: 16 start-page: 723 year: 2012 ident: 2022031223273187900_B36 article-title: Hyperinsulinemia drives diet-induced obesity independently of brain insulin production publication-title: Cell Metab doi: 10.1016/j.cmet.2012.10.019 – volume: 105 start-page: 1574 year: 2011 ident: 2022031223273187900_B39 article-title: Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis publication-title: J Neurophysiol doi: 10.1152/jn.00866.2010 – volume: 132 start-page: 2131 year: 2007 ident: 2022031223273187900_B3 article-title: Biology of incretins: GLP-1 and GIP publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.03.054 – volume: 59 start-page: 1228 year: 2010 ident: 2022031223273187900_B9 article-title: Glucose intolerance and reduced proliferation of pancreatic β-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function publication-title: Diabetes doi: 10.2337/db09-0519 – volume: 113 start-page: 635 year: 2004 ident: 2022031223273187900_B16 article-title: Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors publication-title: J Clin Invest doi: 10.1172/JCI200420518 – volume: 3 start-page: 80 year: 2012 ident: 2022031223273187900_B17 article-title: Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance publication-title: J Diabetes Invest doi: 10.1111/j.2040-1124.2011.00143.x – volume: 280 start-page: 22297 year: 2005 ident: 2022031223273187900_B10 article-title: Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression publication-title: J Biol Chem doi: 10.1074/jbc.M500540200 – volume: 288 start-page: 1929 year: 2013 ident: 2022031223273187900_B15 article-title: Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity publication-title: J Biol Chem doi: 10.1074/jbc.M112.423137 – volume: 283 start-page: 18365 year: 2008 ident: 2022031223273187900_B19 article-title: Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet publication-title: J Biol Chem doi: 10.1074/jbc.M710466200 – volume: 295 start-page: E648 year: 2008 ident: 2022031223273187900_B20 article-title: Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.90440.2008 – volume: 24 start-page: 110 year: 2003 ident: 2022031223273187900_B27 article-title: GIP or not GIP? That is the question publication-title: Trends Pharmacol Sci doi: 10.1016/S0165-6147(03)00031-2 |
| SSID | ssj0006060 |
| Score | 2.5073342 |
| Snippet | Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation. We explored... |
| SourceID | proquest pubmed pascalfrancis crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 2332 |
| SubjectTerms | Animals Biological and medical sciences Body Weight - genetics Diabetes. Impaired glucose tolerance Diet, High-Fat Down-Regulation - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gastric Inhibitory Polypeptide - genetics Gastric Inhibitory Polypeptide - secretion Gene Knock-In Techniques Genotype & phenotype Glucose Glucose - metabolism Homeostasis Insulin resistance Insulin Resistance - genetics Insulin-Secreting Cells - metabolism Male Medical sciences Metabolic diseases Mice Mice, Transgenic Obesity Obesity - metabolism Obesity - therapy Polypeptides Receptors, Gastrointestinal Hormone - genetics Receptors, Gastrointestinal Hormone - metabolism Rodents |
| Title | Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24584548 https://www.proquest.com/docview/1637642322 https://www.proquest.com/docview/1540710633 |
| Volume | 63 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fb9MwELfKkBDShPhPYUwG8YCEwhLHsZPHCRgDtAnBJpWnyLEdgbq105o80K_Cl-Uudp2sDGnwEiVXO0lzP5_vzndnQl4ooYzUMNI0t0UECBFRZbSOWJVUqUl0bC36IQ8Oxf4x_zjJJqPRr0HUUttUr_Xy0ryS_-Eq0ICvmCX7D5wNNwUCnAN_4QgchuOVeOwr28I3Mq4ILKp-7z98Ri86ZicCYfcE88dRoXzl9wDwEcAuBP0LkFA_1Kh9YlkJjPuI9lQDstA2mA9ofvQuPa_Evh34a9d38hl4Fg4VIGgxVX0mu-rl3bkyyq8buUgwtzK1bN022p_Usv0Z6N_UqQ_J_fq9hTef2qGzIuEhsDUI4IRhRVQ3x1onc4u0iFImJ0Oh7KWeA58cStjU-0Otv3RVntZnAmiGa9GmStIITNS0n-5WS_xrs2CITQSrCDuX2LXErtfIdSZlFwPQuYL8NA-Wn8tv8v_Ila3CrjvhqReUnc0ztYBxV7sNU_5u0XSazdFtcsubJHTX4esOGdnZXXLjwAdd3CNTDzMaYEbnNQWY0QAz2sOMephRgBn1MKM9zGgHM7qCGUWY0R5m98nx3rujN_uR36MDBjdjTSRiAzqmqBVPLZgKSVEzozPLdaxSU9W80GAP6FzwnIM00NKKWOdVra1J8iKzNn1ANmbzmX1EKJeqlllSMY1LwXGR66qwYAAKoDBr4zF5ufqYpfYF7HEflZPyD5aNyfPQ9MxVbbms0fYFjoSWLBcxtJRjsrViUelH_aIE-0UKjG5gY_Is_AwyGRfaYCzMW2jTVbUE5R-e8dCxtr85BiZkPH98lVd8Qm72o2iLbDTnrX0KSnBTbXdg_A1RI7HU |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+Reduction+of+GIP+Secretion+Alleviates+Obesity+and+Insulin+Resistance+Under+High-Fat+Diet+Conditions&rft.jtitle=Diabetes+%28New+York%2C+N.Y.%29&rft.au=Nasteska%2C+Daniela&rft.au=Harada%2C+Norio&rft.au=Suzuki%2C+Kazuyo&rft.au=Yamane%2C+Shunsuke&rft.date=2014-07-01&rft.issn=0012-1797&rft.eissn=1939-327X&rft.volume=63&rft.issue=7&rft.spage=2332&rft.epage=2343&rft_id=info:doi/10.2337%2Fdb13-1563&rft.externalDBID=n%2Fa&rft.externalDocID=10_2337_db13_1563 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-1797&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-1797&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-1797&client=summon |