Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice

• Published in: Pharmacological research Vol. 180; p. 106240
• Main Authors: Zhu, Jiale, Jin, Zhiwei, Yang, Lei, Zhao, Caili, Hu, Jianping, Chen, Jinhu, Han, Yubao, Yu, Pei, Luo, Jun, Kong, Lingyi, Zhang, Chao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2022; Elsevier
• Subjects: Angiogenesis; CCT-β; Creatine Kinase B; Ginkgolide B; Ischemic stroke; YKT; CBF; DARTS; Ischemic stroke; Ginkgolide B; Angiogenesis; Ccr; VCSA; CCT-β; SK1; MVD; Creatine Kinase B; CKB

Promoting angiogenesis in the ischemic penumbra is a well-established method of ischemic stroke treatment. Ginkgolide B (GB) has long been recognized for its neuroprotective properties following stroke. As previously reported, it appears that stroke-induced neurogenesis and angiogenesis interact or...