Engineering macromolecular nanocarriers for local delivery of gaseous signaling molecules

• Published in: Advanced drug delivery reviews Vol. 179; p. 114005
• Main Authors: Hu, Jinming, Fang, Yuanmeng, Huang, Xumin, Qiao, Ruirui, Quinn, John F., Davis, Thomas P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021
• Subjects: Carbon monoxide; Carbon Monoxide - metabolism; Drug Carriers - chemistry; Drug Stability; Gaseous signaling molecules; Gasotransmitters - administration & dosage; Gasotransmitters - pharmacology; Humans; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Hydrogen-Ion Concentration; Macromolecular Substances - chemistry; Nanocarriers; Nanoparticle Drug Delivery System - chemistry; Nitric oxide; Nitric Oxide - metabolism; Hydrogen sulfide; Carbon monoxide; Nanocarriers; Gaseous signaling molecules; Nitric oxide

[Display omitted] In addition to being notorious air pollutants, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have also been known as endogenous gaseous signaling molecules (GSMs). These GSMs play critical roles in maintaining the homeostasis of living organisms. Importantly,...