Case Report: Successful management of refractory palmoplantar pustulosis with upadacitinib

• Published in: Frontiers in immunology Vol. 16; p. 1476584
• Main Authors: Yang, Boyun, Yu, Hanxiao, Yao, Wo, Wang, Huiying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.03.2025
• Subjects: Aged; anti-IgE; cytokines; Dermatologic Agents - therapeutic use; Female; Heterocyclic Compounds, 3-Ring - therapeutic use; Humans; Immunology; Janus kinase inhibitors; palmoplantar pustulosis; Psoriasis - diagnosis; Psoriasis - drug therapy; Psoriasis - etiology; Quality of Life; SARS-CoV-2 - immunology; Treatment Outcome; upadacitinib; upadacitinib; anti-IgE; palmoplantar pustulosis; cytokines; Janus kinase inhibitors

Palmoplantar Pustulosis (PPP) is a rare chronic skin disorder characterized by recurrent sterile pustules on palms and soles, leading to significant pain and functional impairment. Treatments include topical medications, phototherapy, systemic treatments, and biologics, but nonconclusive strategy ex...