Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock

• Published in: Pharmacology, biochemistry and behavior Vol. 71; no. 1; pp. 223 - 231
• Main Authors: Luchowska, Elżbieta, Luchowski, Piotr, Wielosz, Marian, Kleinrok, Zdzisław, Czuczwar, Stanisław J., Urbańska, Ewa M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2002; Elsevier Science
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Animals; Anticonvulsant drugs; Anticonvulsants - metabolism; Anticonvulsants - therapeutic use; Anticonvulsants. Antiepileptics. Antiparkinson agents; Behavior, Animal - drug effects; Behavior, Animal - physiology; Biological and medical sciences; Catecholaminergic system; Diazepam; Diazepam - metabolism; Diazepam - therapeutic use; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy; Male; Maximal electroshock-induced seizures; Medical sciences; Metoprolol; Metoprolol - therapeutic use; Mice; Motor Activity - drug effects; Motor Activity - physiology; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Propranolol; Propranolol - therapeutic use; Valproate; Valproic Acid - metabolism; Valproic Acid - therapeutic use; β-Adrenergic receptor antagonist; Maximal electroshock-induced seizures; Metoprolol; Epilepsy; Anticonvulsant drugs; Propranolol; β-Adrenergic receptor antagonist; Diazepam; Valproate; Nervous system diseases; Drug combination; Intraperitoneal administration; Rodentia; Anticonvulsant; Valproate semisodium; Cerebral disorder; β-Adrenergic receptor; Locomotion; Vertebrata; Mammalia; Convulsion; Mouse; Animal; Central nervous system disease; Benzodiazepine derivatives; Drug interaction; Antagonist; Neurological disorder

The anticonvulsive potential of classical antiepileptics co-administered with β-adrenergic receptor antagonists against generalized tonic–clonic seizures was evaluated in the model of maximal electroshock (MES)-induced convulsions. Propranolol, acebutolol, metoprolol and atenolol were tested in the...