The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer

• Published in: Clinical cancer research Vol. 24; no. 19; pp. 4763 - 4770
• Main Authors: Barry, Peter, Vatsiou, Alexandra, Spiteri, Inmaculada, Nichol, Daniel, Cresswell, George D., Acar, Ahmet, Trahearn, Nicholas, Hrebien, Sarah, Garcia-Murillas, Isaac, Chkhaidze, Kate, Ermini, Luca, Huntingford, Ian Said, Cottom, Hannah, Zabaglo, Lila, Koelble, Konrad, Khalique, Saira, Rusby, Jennifer E., Muscara, Francesca, Dowsett, Mitch, Maley, Carlo C., Natrajan, Rachael, Yuan, Yinyin, Schiavon, Gaia, Turner, Nicholas, Sottoriva, Andrea
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018
• Subjects: Adult; Aged; Aged, 80 and over; Axilla - pathology; Breast Neoplasms - blood; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Circulating Tumor DNA - blood; Clonal Evolution - genetics; Female; Gene Expression Regulation, Neoplastic - genetics; Humans; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphatic Metastasis - genetics; Lymphatic Metastasis - pathology; Middle Aged; Neoplasm Proteins - blood; Neoplasm Staging

Purpose: The most significant prognostic factor in early breast cancer is lymph node involvement. This stage between localized and systemic disease is key to understanding breast cancer progression; however, our knowledge of the evolution of lymph node malignant invasion remains limited, as most cur...