Protein growth factors loaded highly porous chitosan scaffold: A comparison of bone healing properties

• Published in: Materials Science & Engineering C Vol. 33; no. 3; pp. 1267 - 1275
• Main Authors: Nandi, Samit K., Kundu, Biswanath, Basu, Debabrata
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2013
• Subjects: Animal model; Animals; Bone Morphogenetic Protein 2 - pharmacology; Bone remodeling; Chitosan - pharmacology; Female; Fluorescent Dyes - metabolism; Growth factor; Humans; Insulin-Like Growth Factor I - pharmacology; Male; Materials Testing; Microscopy, Electron, Scanning; Osteoblasts; Porosity; Porous chitosan; Rabbits; Radiography; Spectroscopy, Fourier Transform Infrared; Tibia - diagnostic imaging; Tibia - drug effects; Tibia - pathology; Tibia - ultrastructure; Tissue Scaffolds - chemistry; Wound Healing - drug effects; Animal model; Porous chitosan; Bone remodeling; Osteoblasts; Growth factor

Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85±2%) with wide distribution of macroporous (70–900μm) chitosan scaffolds were...