Contribution of main chain and side chain atoms and their locations to the stability of thermophilic proteins

• Published in: Journal of molecular graphics & modelling Vol. 64; pp. 85 - 93
• Main Authors: Tompa, Dharma Rao, Gromiha, M.Michael, Saraboji, K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016
• Subjects: Amino acid properties; Amino acids; Amino Acids - chemistry; Chains; Charging; Contact; Free energy; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Hydrophobic free energy; Mathematical models; Models, Molecular; Protein Conformation; Protein Stability; Proteins; Proteins - chemistry; Thermal stability; Thermodynamics; Thermophiles; Thermophilic proteins; Thermophilic proteins; Hydrophobic free energy; Amino acid properties; Thermal stability

[Display omitted] •Systematic structural study on larger dataset of thermophilic-mesophilic homologues.•Factors responsible for increased stability of thermophilic proteins are explored.•Hydrophobic free energy due to C, N+ and O atoms are stronger in thermophiles.•H-bonds in buried to exposed regio...