A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex

• Published in: Development (Cambridge) Vol. 141; no. 15; pp. 3022 - 3032
• Main Authors: Kröcher, Tim, Röckle, Iris, Diederichs, Ute, Weinhold, Birgit, Burkhardt, Hannelore, Yanagawa, Yuchio, Gerardy-Schahn, Rita, Hildebrandt, Herbert
• Format: Journal Article
• Language: English
• Published: England 01.08.2014
• Subjects: Animals; Apoptosis; Calbindins - metabolism; Cell Movement; Genetic Variation; Green Fluorescent Proteins - metabolism; Interneurons - metabolism; Mice; Mice, Inbred C57BL; Neural Cell Adhesion Molecules - metabolism; Neurons - metabolism; Parvalbumins - metabolism; Phenotype; Prefrontal Cortex - cytology; Sialic Acids - metabolism; Sialyltransferases - genetics; Somatostatin - metabolism; Neural cell adhesion molecule; Cortical interneuron migration; NCAM; Mouse prefrontal cortex; Protein glycosylation; Somatostatin; Parvalbumin

Polysialic acid (polySia) is a unique glycan modification of the neural cell adhesion molecule NCAM and a major determinant of brain development. Polysialylation of NCAM is implemented by the two polysialyltransferases (polySTs) ST8SIA2 and ST8SIA4. Dysregulation of the polySia-NCAM system and varia...