Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression

• Published in: Oncotarget Vol. 8; no. 70; pp. 115164 - 115178
• Main Authors: Hong, Se Hoon, Lee, Dae-Hee, Lee, Young-Sun, Jo, Min Jee, Jeong, Yoon A, Kwon, William T, Choudry, Haroon A, Bartlett, David L, Lee, Yong J
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 29.12.2017
• Subjects: Research Paper; apoptosis; ferroptosis; PUMA; ER; p53

Ferroptosis is a type of programmed cell death that depends on iron and is characterized by the accumulation of lipid peroxides. In the present study, we investigated the nature of the interplay between ferroptosis and other forms of cell death such as apoptosis. Human pancreatic cancer PANC-1 and B...