Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 42; no. 8; pp. 655 - 668
• Main Authors: Yamamoto, Hiroshi, Unbehaun, Anett, Spahn, Christian M.T.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2017
• Subjects: 5' Untranslated Regions - genetics; eukaryotic translation initiation; internal ribosome entry site; Internal Ribosome Entry Sites - genetics; Nucleic Acid Conformation; ribosome; Ribosomes - chemistry; Ribosomes - genetics; Ribosomes - metabolism; ribosome; internal ribosome entry site; eukaryotic translation initiation

Internal initiation is a 5′-end-independent mode of translation initiation engaged by many virus- and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 5′ untranslated region (UTR) of the r...