ZDHHC7-mediated S-palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation

• Published in: Autophagy Vol. 20; no. 12; pp. 2719 - 2737
• Main Authors: Wei, Fujing, Wang, Yu, Yao, Jia, Mei, Ligang, Huang, Xue, Kong, Hesheng, Chen, Jing, Chen, Xiaorong, Liu, Lu, Wang, Zhuolin, Wang, Jiaxin, Song, Jiong, Kong, Eryan, Yang, Aimin
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2024
• Subjects: Acetyltransferases; Acyltransferases - metabolism; ATG16L1; autophagosome; Autophagosomes - metabolism; autophagy; Autophagy - physiology; Autophagy-Related Proteins - genetics; Autophagy-Related Proteins - metabolism; HEK293 Cells; HeLa Cells; Humans; LC3-II; Lipoylation; Microtubule-Associated Proteins - metabolism; Research Paper; S-palmitoylation; ZDHHC7; S-palmitoylation; LC3-II; ZDHHC7; autophagy; ATG16L1; autophagosome

Macroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded. Autophagy recycles cytoplasmic components, including misfolded proteins, dysf...