Transcriptome analysis in human breast milk and blood in a randomized trial after inactivated or attenuated influenza immunization

• Published in: npj vaccines Vol. 10; no. 1; pp. 53 - 9
• Main Authors: Schlaudecker, Elizabeth P., Jensen, Travis L., Gelber, Casey E., Dexheimer, Phillip J., Steinhoff, Mark C., Bernstein, David I., Goll, Johannes B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.03.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/255/1578; 631/250/590/1867; 631/250/590/1883; 631/326/590/1867; 631/326/590/1883; Antibodies; Babies; Biomedical and Life Sciences; Biomedicine; Breast feeding; Breast milk; Breastfeeding & lactation; Gene expression; Genomics; Illnesses; Immunity (Disease); Immunization; Immunoglobulins; Infectious Diseases; Lymphocytes; Medical Microbiology; Postpartum period; Public Health; Swine flu; Umbilical cord; Vaccine; Vaccines; Virology; Womens health

Transcriptomic signatures were identified in human peripheral blood mononuclear cells (PBMCs) and breast milk lymphocyte (BML) cells induced by trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV) administered after delivery. We performed an RNA-Seq analysis on b...