Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine

• Published in: Neuropharmacology Vol. 41; no. 8; pp. 935 - 942
• Main Authors: Fernández-Sánchez, M.Teresa, Dı́az-Trelles, Ramón, Groppetti, Antonio, Manfredi, Barbara, Brini, Anna T, Biella, Gabriele, Sotgiu, Maria Luisa, Novelli, Antonello
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2001; Elsevier
• Subjects: Analgesics, Non-Narcotic - pharmacology; Animals; Biological and medical sciences; Cell Death - drug effects; Cell Death - physiology; Cells, Cultured; Cerebellum - cytology; Cerebellum - drug effects; Cerebellum - physiology; Cultured cerebellar neurons; Cyclic GMP - antagonists & inhibitors; Cyclic GMP - biosynthesis; Dose-Response Relationship, Drug; Excitotoxicity; Glutamate release; Medical sciences; Nefopam; Nefopam - pharmacology; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Rats; Reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Sodium channels; Veratridine - pharmacology; Sodium channels; Glutamate release; Reactive oxygen species; Cultured cerebellar neurons; Nefopam; Excitotoxicity; Cerebellum; Rat; Toxicity; Central nervous system; Glutamate receptor; Ionic channel; Free radical; Prevention; Sodium ion; Mechanism of action; Nervous system diseases; Rodentia; 3',5'-GMP; Neuroprotective agent; Glutamate; In vitro; Biological activity; Cerebral disorder; Vertebrata; Chemotherapy; Mammalia; Analgesic; Cell death; Animal; Central nervous system disease; Excitatory aminoacid; NMDA receptor; Brain (vertebrata)

Nefopam hydrochloride is a potent analgesic compound that possesses a profile distinct from that of opiods or anti-inflammatory drugs. Previous evidence suggested a central action of nefopam but the detailed mechanisms remain unclear. Here we have used cultured cerebellar neurons to test the hypothe...