Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus

• Published in: Neurotoxicology (Park Forest South) Vol. 34; pp. 243 - 253
• Main Authors: Wu, Jie, Ding, Tingting, Sun, Jiao
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.01.2013; Elsevier
• Subjects: Administration, Intranasal; Animals; Apoptosis - drug effects; Basal Ganglia - drug effects; Basal Ganglia - metabolism; Basal Ganglia - pathology; Biological and medical sciences; Cell Cycle Checkpoints - drug effects; Cell Survival - drug effects; Chemical and industrial products toxicology. Toxic occupational diseases; Dopaminergic neuron; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Enzyme Activation; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Iron oxide nanoparticles; JNK; JNK Mitogen-Activated Protein Kinases - metabolism; Magnetite Nanoparticles - administration & dosage; Magnetite Nanoparticles - toxicity; Male; Medical sciences; Metals and various inorganic compounds; Neurotoxicity; Neurotoxicity Syndromes - etiology; Neurotoxicity Syndromes - metabolism; Neurotoxicity Syndromes - pathology; Oxidative stress; Oxidative Stress - drug effects; p53; PC12 Cells; Rats; Rats, Sprague-Dawley; Striatum; Time Factors; Tissue Distribution; Toxicology; Tumor Suppressor Protein p53 - metabolism; Striatum; Oxidative stress; Neurotoxicity; Iron oxide nanoparticles; JNK; Dopaminergic neuron; Hippocampus; p53; Rat; Nanoparticle; Toxicity; Central nervous system; Oxides; Nervous system; Iron; Ultrafine particle; Encephalon; TP53 Gene; Tumor suppressor gene; Nervous system diseases; Enzyme; Transferases; Rodentia; Mitogen-activated protein kinase; Transition metal; Basal ganglion; Corpus striatum; Vertebrata; Mammalia; Animal; Nanostructured materials

► Fe3O4-NPs deposit in striatum and hippocampus related PD and AD. ► Fe3O4-NPs decrease neurons viability, trigger oxidative stress in vitro. ► JNK/P53 signalling pathway is activated by Fe3O4-NPs at 100μg/ml. It has recently been reported that iron oxide nanoparticles (Fe3O4-NPs, 30nm) have the abi...