Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice
Nitric oxide (NO) is a retrograde messenger involved in the processes of learning and memory. The role of the endothelial isoform of nitric oxide synthase (eNOS) in striatal synaptic plasticity was investigated in eNOS-deficient (eNOS −/−) and wild type (WT) mice. Tetanic stimulation of cortical aff...
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Published in | Brain research Vol. 964; no. 1; pp. 159 - 163 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Elsevier B.V
21.02.2003
Amsterdam Elsevier New York, NY |
Subjects | |
Online Access | Get full text |
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Summary: | Nitric oxide (NO) is a retrograde messenger involved in the processes of learning and memory. The role of the endothelial isoform of nitric oxide synthase (eNOS) in striatal synaptic plasticity was investigated in eNOS-deficient (eNOS
−/−) and wild type (WT) mice. Tetanic stimulation of cortical afferents in WT mice evoked either long-term potentiation (LTP), or long-term depression (LTD) of cortico-striatal transmission. Both these plasticity related phenomena were NMDA-receptor-dependent; LTD was blocked by sulpiride, a dopamine D2-receptor antagonist. LTP occurrence in slices from eNOS
−/− mice was significantly reduced when compared with WT mice. The NOS inhibitor NL-ARG reduced the occurrence of LTP and increased the occurrence of LTD in WT mice, resembling the balance of LTP/LTD in eNOS
−/− mice. Impairment of NO-synthesis thus shifts striatal plasticity towards LTD. This indicates a possible involvement of eNOS from endothelia in neuronal modulation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/S0006-8993(02)04121-5 |