An introduction to the use of tracers in nutrition and metabolism
The present article is a review written at a level suitable for students and new workers to the field of techniques in common current use for the measurement of static and dynamic features of metabolism, especially nutritional metabolism. It covers the nature of radioactive and stable-isotope tracer...
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| Published in | Proceedings of the Nutrition Society Vol. 58; no. 4; pp. 935 - 944 |
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| Main Author | |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.11.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present article is a review written at a level suitable for students and new workers to the field of techniques in common current use for the measurement of static and dynamic features of metabolism, especially nutritional metabolism. It covers the nature of radioactive and stable-isotope tracers, the means of measuring them, and the advantages and disadvantages of their use. The greater part of the review deals with methods for the measurement of pool sizes and metabolic processes, with the emphasis being on protein metabolism, a field the author knows best. The examples given are from a variety of sources, including the work of the author, but the principles underlying the techniques are universally applicable to all metabolic investigations using tracers. |
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| AbstractList | The present article is a review written at a level suitable for students and new workers to the field of techniques in common current use for the measurement of static and dynamic features of metabolism, especially nutritional metabolism. It covers the nature of radioactive and stable-isotope tracers, the means of measuring them, and the advantages and disadvantages of their use. The greater part of the review deals with methods for the measurement of pool sizes and metabolic processes, with the emphasis being on protein metabolism, a field the author knows best. The examples given are from a variety of sources, including the work of the author, but the principles underlying the techniques are universally applicable to all metabolic investigations using tracers. |
| Author | Rennie, Michael J. |
| Author_xml | – sequence: 1 givenname: Michael J. surname: Rennie fullname: Rennie, Michael J. email: m.j.rennie@dundee.ac.uk organization: Department of Anatomy and Physiology, University of Dundee, Dundee DD1 4HN, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10817161$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/jn/128.9.1562 10.1126/science.7302583 10.1017/S0029665199001172 10.1073/pnas.88.13.5892 10.1002/bms.1200211004 10.1080/10408399109527549 10.1042/bst020102s 10.1017/S0029665199001251 10.1007/PL00014267 10.1016/0026-0495(81)90067-6 10.1042/bj1860381 10.1038/4772 10.1042/bst0240927 10.1177/0148607192016004305 10.1017/S0029665199001214 10.1016/0026-0495(93)90234-F 10.1113/expphysiol.1984.sp002829 10.1016/0261-5614(92)90281-T 10.1136/gut.33.5.675 10.1073/pnas.92.22.10123 10.1016/0009-8981(96)06300-0 10.1007/978-1-4612-4654-1 10.1042/cs0810557 10.1002/rcm.1290060704 10.1093/ajcn/35.5.1033 |
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| References | Zhang (S002966519900124X_ref041) 1996; 270 Rennie (S002966519900124X_ref025) 1992; 20 S002966519900124X_ref020 Smith (S002966519900124X_ref029) 1992; 51 S002966519900124X_ref040 S002966519900124X_ref038 S002966519900124X_ref016 S002966519900124X_ref017 S002966519900124X_ref014 S002966519900124X_ref015 S002966519900124X_ref037 Smith (S002966519900124X_ref027) 1992; 262 Bennet (S002966519900124X_ref002) 1990; 49 S002966519900124X_ref012 Smith (S002966519900124X_ref031) 1998; 38 Chien (S002966519900124X_ref008) 1993; 265 S002966519900124X_ref035 S002966519900124X_ref013 S002966519900124X_ref032 S002966519900124X_ref010 S002966519900124X_ref033 Wolfe (S002966519900124X_ref039) 1992 Turnlund (S002966519900124X_ref034) 1982; 35 S002966519900124X_ref018 S002966519900124X_ref019 Corbett (S002966519900124X_ref011) 1995; 32 Cobelli (S002966519900124X_ref009) 1987; 253 S002966519900124X_ref005 S002966519900124X_ref028 Meier-Augenstein (S002966519900124X_ref021) 1997; 15 S002966519900124X_ref003 Scrimgeour (S002966519900124X_ref026) 1993; 52 S002966519900124X_ref004 S002966519900124X_ref023 S002966519900124X_ref001 S002966519900124X_ref024 Smith (S002966519900124X_ref030) 1990 Nakshabendi (S002966519900124X_ref022) 1995; 269 Watt (S002966519900124X_ref036) 1992; 263 S002966519900124X_ref007 Boza (S002966519900124X_ref006) 1996; 126 |
| References_xml | – ident: S002966519900124X_ref023 doi: 10.1093/jn/128.9.1562 – volume: 269 start-page: E996 year: 1995 ident: S002966519900124X_ref022 article-title: Gut mucosal protein synthesis measured using intravenous and intragastric delivery of stable tracer amino acids publication-title: American Journal of Physiology contributor: fullname: Nakshabendi – ident: S002966519900124X_ref019 doi: 10.1126/science.7302583 – ident: S002966519900124X_ref017 doi: 10.1017/S0029665199001172 – ident: S002966519900124X_ref037 doi: 10.1073/pnas.88.13.5892 – ident: S002966519900124X_ref040 doi: 10.1002/bms.1200211004 – ident: S002966519900124X_ref033 doi: 10.1080/10408399109527549 – ident: S002966519900124X_ref010 doi: 10.1042/bst020102s – ident: S002966519900124X_ref038 doi: 10.1017/S0029665199001251 – volume: 262 start-page: E372 year: 1992 ident: S002966519900124X_ref027 article-title: Flooding with L-[1-13C\leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C\valine publication-title: American Journal of Physiology contributor: fullname: Smith – volume: 20 start-page: 63 year: 1992 ident: S002966519900124X_ref025 article-title: Methods of assessment of muscle protein turnover and their application to problems in clinical nutrition publication-title: Rivista Italiana di Nutrizione Parenterale et Enterale contributor: fullname: Rennie – ident: S002966519900124X_ref014 doi: 10.1007/PL00014267 – volume: 52 year: 1993 ident: S002966519900124X_ref026 article-title: Collagen synthesis in human bone using stable-isotope-labelled alanine and proline publication-title: Proceedings of the Nutrition Society contributor: fullname: Scrimgeour – ident: S002966519900124X_ref020 doi: 10.1016/0026-0495(81)90067-6 – volume: 51 year: 1992 ident: S002966519900124X_ref029 article-title: A multi-tracer investigation of the effect of a flooding dose administered during the constant infusion of tracer amino acid on the rate of tracer incorporation into human muscle protein publication-title: Proceedings of the Nutrition Society contributor: fullname: Smith – volume: 49 year: 1990 ident: S002966519900124X_ref002 article-title: L-[15N\Phenylalanine and L-[l-13C\leucine leg exchange and plasma kinetics during amino acid infusion and euglycaemic hyperinsulinaemia; evidence for stimulation of muscle and whole-body protein synthesis in man by insulin publication-title: Proceedings of the Nutrition Society contributor: fullname: Bennet – start-page: 461 volume-title: Ballière's Clinical Endocrinology and Metabolism: Muscle Metabolism year: 1990 ident: S002966519900124X_ref030 contributor: fullname: Smith – ident: S002966519900124X_ref016 doi: 10.1042/bj1860381 – volume: 38 start-page: E73 year: 1998 ident: S002966519900124X_ref031 article-title: Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein publication-title: American Journal of Physiology contributor: fullname: Smith – volume: 263 start-page: 453 year: 1992 ident: S002966519900124X_ref036 article-title: Stimulation of protein synthesis in pig skeletal muscle by infusion of amino acids during constant insulin availability publication-title: American Journal of Physiology contributor: fullname: Watt – ident: S002966519900124X_ref013 doi: 10.1038/4772 – ident: S002966519900124X_ref024 doi: 10.1042/bst0240927 – ident: S002966519900124X_ref005 doi: 10.1177/0148607192016004305 – volume: 270 start-page: E759 year: 1996 ident: S002966519900124X_ref041 article-title: An isotopic method for measurement of muscle protein fractional breakdown rate in vivo publication-title: American Journal of Physiology contributor: fullname: Zhang – ident: S002966519900124X_ref001 doi: 10.1017/S0029665199001214 – ident: S002966519900124X_ref003 doi: 10.1016/0026-0495(93)90234-F – ident: S002966519900124X_ref035 doi: 10.1113/expphysiol.1984.sp002829 – ident: S002966519900124X_ref028 doi: 10.1016/0261-5614(92)90281-T – ident: S002966519900124X_ref032 doi: 10.1136/gut.33.5.675 – volume: 265 start-page: E31 year: 1993 ident: S002966519900124X_ref008 article-title: Protein-turnover in the human fetus studied at term using stable-isotope tracer amino-acids publication-title: American Journal of Physiology contributor: fullname: Chien – volume-title: Radioactive and Stable-isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis year: 1992 ident: S002966519900124X_ref039 contributor: fullname: Wolfe – volume: 126 start-page: 1749 year: 1996 ident: S002966519900124X_ref006 article-title: Ribonucleic acid nucleotides in maternal and fetal tissues derive almost exclusively from synthesis de novo in pregnant mice publication-title: Journal of Nutrition contributor: fullname: Boza – ident: S002966519900124X_ref004 doi: 10.1073/pnas.92.22.10123 – volume: 15 start-page: 244 year: 1997 ident: S002966519900124X_ref021 article-title: The chromatographic side of isotope ratio mass spectrometry – Pitfalls and answers publication-title: LC–GC Magazine of Separation Science contributor: fullname: Meier-Augenstein – ident: S002966519900124X_ref018 doi: 10.1016/0009-8981(96)06300-0 – ident: S002966519900124X_ref012 doi: 10.1007/978-1-4612-4654-1 – ident: S002966519900124X_ref015 doi: 10.1042/cs0810557 – volume: 253 start-page: E551 year: 1987 ident: S002966519900124X_ref009 article-title: Models to interpret kinetic data in stable isotope tracer studies publication-title: American Journal of Physiology contributor: fullname: Cobelli – ident: S002966519900124X_ref007 doi: 10.1002/rcm.1290060704 – volume: 35 start-page: 1033 year: 1982 ident: S002966519900124X_ref034 article-title: Use of enriched stable isotopes to determine zinc and iron absorption in elderly men publication-title: American Journal of Clinical Nutrition doi: 10.1093/ajcn/35.5.1033 contributor: fullname: Turnlund – volume: 32 start-page: E418 year: 1995 ident: S002966519900124X_ref011 article-title: Pentagastrin increases pepsin-secretion without increasing its fractional synthetic rate publication-title: American Journal of Physiology contributor: fullname: Corbett |
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| SubjectTerms | Animals Humans Indicator Dilution Techniques Isotope Labeling Isotopes Isotopic-labelling techniques Metabolism Nucleic Acids - metabolism Nutritional Physiological Phenomena Protein metabolism Proteins - metabolism Radioactive Tracers Stable-isotope tracers |
| Title | An introduction to the use of tracers in nutrition and metabolism |
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