Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review

The association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD pa...

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Published inFrontiers in immunology Vol. 16; p. 1526095
Main Authors Ma, Hongxia, Wang, Ziyuan, Yu, Miao, Zhai, Yibo, Yan, Junqiang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 31.03.2025
Subjects
B lymphocyte
B lymphocyte subsets
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocytes - immunology
Biomarkers
Humans
Immunity
Immunology
Inflammation
Lymphocyte Count
Parkinson Disease - blood
Parkinson Disease - immunology
Parkinson’s disease
Pathogenesis
B lymphocyte
B lymphocyte subsets
Inflammation
Pathogenesis
Immunity
Parkinson’s disease
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Abstract The association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject. PubMed, Cochrane Library, and MEDLINE databases were searched until 3 February 2024. We included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients' peripheral blood. Studies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.
AbstractList The association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject. PubMed, Cochrane Library, and MEDLINE databases were searched until 3 February 2024. We included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients' peripheral blood. Studies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.
The association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.PubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.MethodsPubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.We included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients' peripheral blood.ResultsWe included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients' peripheral blood.Studies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.ConclusionStudies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.
ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence in the alterations of B lymphocytes or B lymphocyte subsets in peripheral blood of PD patients. To comprehensively understand its changes in PD patients,it is necessary to conduct a systematic review on this subject.MethodsPubMed, Cochrane Library, and MEDLINE databases were searched until 3rd February 2024.ResultsWe included 20 studies (n=2658) to conduct this systematic review. We conducted a qualitative analysis to assess the alterations of B lymphocytes and B lymphocyte subsets in the peripheral blood of individuals with PD. And studies reviewed demonstrated a significant decrease in the number of B cells, as well as immune dysregulation in the B lymphocyte subsets of these patients’ peripheral blood.ConclusionStudies reviewed demonstrated that PD is linked to abnormalities in B lymphocytes and/or B lymphocytes subsets in peripheral blood. This study provides a novel perspective into the pathogenesis of PD, and future investigations into the B lymphocytes and/or B lymphocyte subsets as biomarkers and therapeutic targets for PD is warranted.
Author Wang, Ziyuan
Yu, Miao
Yan, Junqiang
Zhai, Yibo
Ma, Hongxia
AuthorAffiliation 1 Department of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology , Luoyang , China
2 Key laboratory of Neuromolecular Biology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology , Luoyang , China
AuthorAffiliation_xml – name: 1 Department of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology , Luoyang , China
– name: 2 Key laboratory of Neuromolecular Biology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology , Luoyang , China
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Keywords B lymphocyte
B lymphocyte subsets
Inflammation
Pathogenesis
Immunity
Parkinson’s disease
Language English
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Thiru Vanniasinkam, Charles Sturt University, Australia
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Snippet The association of B lymphocytes and B lymphocyte subsets and Parkinson's disease (PD) is increasingly acknowledged. However, there is inconsistence in the...
ObjectiveThe association of B lymphocytes and B lymphocyte subsets and Parkinson’s disease (PD) is increasingly acknowledged. However, there is inconsistence...
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SubjectTerms B lymphocyte
B lymphocyte subsets
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocytes - immunology
Biomarkers
Humans
Immunity
Immunology
Inflammation
Lymphocyte Count
Parkinson Disease - blood
Parkinson Disease - immunology
Parkinson’s disease
Pathogenesis
Title Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review
URI https://www.ncbi.nlm.nih.gov/pubmed/40230858
https://www.proquest.com/docview/3190336211
https://pubmed.ncbi.nlm.nih.gov/PMC11994702
https://doaj.org/article/e33e4742e8e2438a92cda6cf245e653b
Volume 16
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