Mitochondrial antioxidants abate SARS-COV-2 pathology in mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 30; p. e2321972121
• Main Authors: Guarnieri, Joseph W., Lie, Timothy, Albrecht, Yentli E. Soto, Hewin, Peter, Jurado, Kellie A., Widjaja, Gabrielle A., Zhu, Yi, McManus, Meagan J., Kilbaugh, Todd J., Keith, Kelsey, Potluri, Prasanth, Taylor, Deanne, Angelin, Alessia, Murdock, Deborah G., Wallace, Douglas C.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.07.2024
• Subjects: ACE2; Angiotensin; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antioxidants; Antioxidants - metabolism; Antioxidants - pharmacology; Biological Sciences; Catalase; Catalase - genetics; Catalase - metabolism; Catalytic converters; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 - virology; COVID-19 Drug Treatment; Disease Models, Animal; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Evolution; Gene expression; Gene sequencing; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Immunity, Innate; Innate immunity; Lung - metabolism; Lung - pathology; Lung - virology; Lungs; Mice; Mice, Transgenic; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial DNA; Oxidative phosphorylation; Oxidative Phosphorylation - drug effects; Pathology; Peptidyl-dipeptidase A; Pharmacology; Phosphorylation; Reactive oxygen species; Reactive Oxygen Species - metabolism; SARS-CoV-2 - drug effects; Severe acute respiratory syndrome coronavirus 2; Viral diseases; Weight loss; SARS-CoV-2; mCAT; EUK8; mitochondria; antioxidant therapy
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.2321972121

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection inhibits mitochondrial oxidative phosphorylation (OXPHOS) and elevates mitochondrial reactive oxygen species (ROS, mROS) which activates hypoxia-inducible factor-1alpha (HIF-1α), shifting metabolism toward glycolysis to drive vir...