Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice

• Published in: Neurotoxicology (Park Forest South) Vol. 38; pp. 9 - 16
• Main Authors: He, Min-Di, Xu, Shang-Cheng, Zhang, Xin, Wang, Yan, Xiong, Jia-Chuan, Zhang, Xiao, Lu, Yong-Hui, Zhang, Lei, Yu, Zheng-Ping, Zhou, Zhou
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2013; Elsevier
• Subjects: Aconitate Hydratase - metabolism; Adenosine Triphosphate - metabolism; Aerobic metabolism; Aerobiosis - drug effects; Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Chemical and industrial products toxicology. Toxic occupational diseases; Down-Regulation; Exploratory Behavior - drug effects; Iron-Sulfur Proteins - metabolism; Iron–sulfur cluster; ISCU; Lactic Acid - metabolism; Male; Maze Learning - drug effects; Medical sciences; Metals and various inorganic compounds; Mice; NAD - metabolism; Neurobehavioral change; Nickel; Nickel - toxicity; Oxidative Stress; Oxygen Consumption - drug effects; Toxicology; NAD/NADH; MWM; Neurobehavioral change; Aerobic metabolism; OXPHOS; SOD; HIF-1α; MDA; Iron–sulfur cluster; ROS; ISC; Nickel; ATP; ISCU; Rodentia; Iron―sulfur cluster; Nervous system; Cluster; Transition metal; Iron; Aerobe; Change; Metabolism; Inorganic element; Vertebrata; Mammalia; Mouse; Animal; Behavior; Sulfur; Morris water maze; iron–sulfur cluster scaffold protein; oxidative phosphorylation; nicotinamide adenine dinucleotide; superoxide dismutase; adenosine triphosphate; reactive oxygen species; malondialdehyde; hypoxia inducible factor-1 alpha

•Transient neurobehavioral effects induced by nickel oral exposure.•Nickel deposition in cerebral cortex causes disturbance of aerobic metabolism.•Alteration in iron sulfur cluster scaffold protein may underlie effects of nickel. The oral ingestion of soluble nickel compounds leads to neurological s...